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Moumoujus

HYDROLYZED PLACENTAL PROTEIN.

Insufficient Data CAS 91080-01-2 / ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING

Hydrolyzed Placental Protein, derived from bovine placenta, is a complex blend of amino acids, peptides, and proteins. In skincare, it aims to deliver moisturizing, nourishing, and regenerative benefits, primarily by enhancing skin hydration and forming a protective barrier.

Summary

Moisturizing Nourishing Regenerating Film-forming Protecting Restructuring Skin Conditioning Hair Conditioning Antistatic Improves surface hydration and elasticity Reduces trans-epidermal-water-loss

Science

Mechanism of Action

This ingredient functions by supplying a rich array of amino acids, which are crucial for improving surface hydration and boosting skin elasticity. Its larger peptide and protein components create a beneficial film on the skin's surface, effectively reducing trans-epidermal water loss (TEWL). This action helps maintain optimal skin cell water content, promoting a healthier complexion. Beyond hydration, it is thought to support faster cell regeneration, stimulate collagen production, offer protection against environmental damage, and contribute to calming the skin, potentially mitigating redness and hyperpigmentation by stimulating cellular metabolism and circulation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

For related protein hydrolysates from placenta extract, stability was compromised at highly acidic (pH 2.0) and alkaline (pH 10.0) conditions. Greater stability was observed within the pH range of 4-6.

Conflicts

  • Substances with estrogenic or other biological activity (should be removed from cosmetic formulations)
  • Pathogenic viruses or infectious agents (ingredients must be free of these)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has stated that available data are insufficient to support the safety of this ingredient in cosmetics, requesting further data on sensitization, repeated exposure toxicity, reproductive/developmental toxicity, photosensitization, genotoxicity, and ocular toxicity. Concerns regarding potential endocrine disruption exist, with the weight of evidence being unassessed by CIR. There is a recognized risk of infectious disease transmission, requiring ingredients to be free of detectable pathogens. Human-derived ingredients are prohibited in the European Union due to concerns about the transmission of human spongiform encephalopathies and viral diseases. The FDA advises against labeling hormone-depleted placenta-derived ingredients as 'placenta extract' to prevent consumer deception, while also noting its use as a food additive with limited toxicity information.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Despite some proposed benefits for skin hydration and hair health, the significant gaps in safety data from CIR, alongside concerns about endocrine disruption and pathogen risk, lead to an 'insufficient-data' verdict for comprehensive cosmetic use.

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