HYDROLYZED HUMAN PLACENTAL PROTEIN.

This protein hydrolysate delivers a blend of amino acids, peptides, and larger protein molecules to the skin. Its high amino acid content actively improves surface hydration and skin elasticity. Larger peptide and protein components form a protective film, which effectively reduces trans-epidermal water loss, thereby helping to maintain skin cell water content and promote a healthy complexion. Manufacturers note its role as a film-forming, protecting, and restructuring agent. Research has indicated its ability to reduce reactive oxygen species (ROS) and restore the expression of key cellular components like Nrf2, SOD1, catalase, and filaggrin (FLG) in TNF-α/IFN-γ-stimulated human keratinocytes. It also demonstrated anti-inflammatory effects by reducing markers such as IL-6, TARC, TSLP, and RANTES, inhibiting NF-κB phosphorylation, and suppressing the T helper 2 (Th2) immune response. In a mouse model, it significantly mitigated atopic dermatitis-like symptoms by reducing mast cell and macrophage infiltration, epidermal thickness, and TSLP levels, while preventing FLG downregulation. Further benefits are suggested to include faster cell regeneration, enhanced collagen production, improved moisture retention, protection against environmental damage leading to wrinkles, soothing properties for acne and redness, and contributing to the reduction of hyperpigmentation and dark spots.