Science
Mechanism of Action
This extract reduces melanin synthesis and content, providing measurable protection against UV-induced pigmentation. Its amino acid composition enhances surface hydration and elasticity, forming a protective film to reduce trans-epidermal water loss (TEWL). It strengthens the skin barrier by promoting beneficial microbial growth and antimicrobial peptide expression in epidermal keratinocytes, while also diminishing stratifin expression in aged cells to prevent dryness-induced wrinkles. The extract suppresses IL-6, thereby mitigating wrinkle worsening by preventing the increase of collagen-degrading matrix metalloproteinase (MMP) enzymes. Furthermore, it activates fibroblast mitochondria to boost type I collagen production, improving skin elasticity. It demonstrates significant antioxidant activity (DPPH radical scavenging), promotes fibroblast migration for wound healing, refines pores, regulates excess oil, and possesses antibacterial properties to help reduce acne.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Oral intake of 220 mg daily for 4 weeks significantly decreased melanin synthesis and melanin content in facial skin, offering protection against UV-induced pigmentation in healthy adult women (in vivo).
- 02 Topical application of a cream containing horse placental extract demonstrated potential to improve wrinkles around the corner of the eyes by minimizing maximum wrinkle width and decreasing wrinkle count in healthy women (in vivo).
- 03 Horse placental peptides exhibited significant DPPH radical scavenging activity, indicating robust antioxidant effects (in vitro) at concentrations of 75 µg/mL and 150 µg/mL.
- 04 Horse placental peptides significantly increased mitochondrial activity and promoted type I collagen production in human fibroblasts (in vitro) at 500 µg/mL.
- 05 Horse placental peptides significantly enhanced the migration activity of human fibroblasts in a wound healing assay (in vitro) at 100 µg/mL.
- 06 Horse placental peptides promoted cell proliferation in a three-dimensional human epidermal culture system (in vitro) at concentrations of 15% (W/V) and 50% (W/V).
Transparency
Dusting Analysis
Current research data does not indicate that Hydrolyzed Horse Placenta Extract is commonly 'dusted' in formulations; its efficacy is observed across various in vitro and in vivo studies at specified concentrations.
The Formula
Formulation
Stability
The extract was demonstrated to be stable in a Tris–HCl buffer at pH 7.4 for specific in vitro applications. For general formulation purposes, it is typically extracted using solvents such as water, physiological saline, and lower alcohols. Oil-soluble components, including potential hormones, can be selectively removed using solvents like butanol, hexane, or acetone.
Safety
Safety Profile
Equine placenta is considered relatively safe and noninvasive, possessing low antigenicity and allergenicity, which minimizes the risk of allergic reactions. Clinical studies, encompassing both oral and topical applications, have consistently reported no adverse events or side effects. It is important to distinguish equine placenta from human placental extracts, which are restricted in EU and US cosmetics due to concerns regarding disease transmission and hormones; these restrictions do not apply to equine-derived ingredients.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Horse Placenta Extract presents a valuable profile for precision skincare, offering scientifically supported benefits across anti-aging, skin brightening, hydration, and barrier enhancement.
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