Science
Mechanism of Action
This extract primarily functions by attracting and retaining moisture within the skin, acting as a humectant. It also serves as a skin-conditioning agent, helping to maintain the skin's healthy appearance, and provides emollient benefits that soften and smooth the skin's surface. Broadly, amniotic products are understood to operate as biological scaffolds, supplying essential growth factors, chemokines, and cytokines. These components are believed to support tissue repair and enhance overall tissue quality through potential antimicrobial, anti-apoptotic, anti-fibrotic, angiogenic, and regenerative pathways.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
No specific optimal pH range for stability in cosmetic formulations has been identified. The term 'hydrolyzed' indicates that the extract is formed through a reaction with water, often facilitated by enzymes. For comparison, raw equine amnion used in veterinary applications is sometimes preserved in acidic solutions like 0.25% acetic acid, suggesting a potential tolerance to certain acidic conditions.
Safety
Safety Profile
Specific safety assessments by the Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) for Hydrolyzed Horse Amnion Extract are not available. A critical regulatory consideration within the European Union is Regulation 1223/2009, Annex II, entry 419, which prohibits Category 1 and 2 animal by-products, as defined by Regulation 1069/2009, and their derived ingredients in cosmetic products. The EU's CosIng database lists 'Hydrolyzed Horse Amnion/Placenta/Umbilical Extract' with a note indicating that applicability of this provision must be considered. The FDA has not issued a specific cosmetic status for this ingredient; however, general hydrolyzed proteins are considered Generally Recognized As Safe (GRAS) when used as flavoring agents in foods.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting promising in vitro benefits for wound healing and possessing humectant and emollient properties, the ingredient faces significant regulatory uncertainties in key markets like the EU and lacks comprehensive cosmetic-specific safety and efficacy data, making its widespread inclusion questionable.
Related
Similar Ingredients
Finding similar ingredients…