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HYDROLYZED BEE LARVA/PUPA EXTRACT.

Valuable CAS - / SKIN CONDITIONING - EMOLLIENT

Hydrolyzed Bee Larva/Pupa Extract is a nutrient-rich active derived from honeybee larvae and pupae, offering a complex profile of proteins, amino acids, fatty acids, and minerals. It is precisely formulated to target multiple signs of skin aging and environmental stress, promoting a more youthful and resilient complexion.

Summary

anti-aging antioxidant anti-inflammatory skin-conditioning hydrating

Science

Mechanism of Action

This extract operates through several cellular pathways to improve skin health. It significantly boosts collagen type I synthesis and inhibits the activity of collagenase (MMP1) and hyaluronidase, enzymes responsible for the degradation of structural proteins and hyaluronic acid. Furthermore, it demonstrates potent antioxidant properties by scavenging free radicals (DPPH, ABTS, nitrite) and exhibits anti-inflammatory effects through nitric oxide inhibition. Its rich amino acid profile also contributes to its hygroscopic nature, aiding in maintaining skin hydration.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Current research data does not provide sufficient information to determine common dusting practices or specific thresholds for this ingredient in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Proteins within the extract exhibit solubility and stability influenced by pH and ionic strength. Optimal stability for proteins is typically observed away from their isoelectric point (pI). Related bee proteins, such as major royal jelly proteins, show pH-dependent stability, suggesting similar considerations for this extract.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated Hydrolyzed Bee Larva/Pupa Extract. However, *in vitro* toxicity evaluations of drone pupa extracts demonstrated no cytotoxicity at concentrations up to 25 μg/mL, maintaining cell viability above 90% in human dermal fibroblasts and melanoma cells. Additionally, protein extracts and hydrolysates have shown 'low irritation properties' in a hen's egg chorioallantoic membrane (HET-CAM) test.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydrolyzed Bee Larva/Pupa Extract is a valuable ingredient, demonstrating robust in vitro efficacy in boosting collagen, inhibiting degrading enzymes, and providing antioxidant and anti-inflammatory benefits, with indications of low irritation.

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