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Moumoujus

HYDROCORTISONE ACETATE.

Valuable CAS 50-03-3 / SKIN CONDITIONING

Hydrocortisone Acetate is a synthetic corticosteroid recognized for its potent anti-inflammatory, anti-pruritic, and vasoconstrictive properties. It is a well-established therapeutic agent used topically to alleviate symptoms associated with various inflammatory skin conditions such as eczema and dermatitis.

Summary

Anti-inflammatory Soothing

Science

Mechanism of Action

This ingredient operates by penetrating cell membranes and binding to cytosolic glucocorticoid receptors. The resultant drug-receptor complex then translocates to the cell nucleus, where it modulates gene transcription. Specifically, it inhibits phospholipase A2, thereby reducing the production of pro-inflammatory mediators like prostaglandins and leukotrienes. It also suppresses immune responses by inhibiting lymphocyte proliferation and cytokine release, contributing to its anti-inflammatory and immunosuppressive actions.

Research

Clinical Evidence

High confidence
Effective range 0.5–2.5%
Optimal

N/A

Key findings

  1. 01 Topical hydrocortisone acetate significantly reduces swelling, itching, and redness associated with various skin conditions including eczema, dermatitis, allergies, and rashes.
  2. 02 A topical lotion containing 2.5% hydrocortisone acetate demonstrated a significant reduction in pruritus (itch) within a single day of use in a pilot study.
  3. 03 For the management of mild to moderate atopic dermatitis flares, particularly on sensitive areas like the face, axilla, and genitals, 1% and 2.5% hydrocortisone acetate preparations are typically sufficient and recommended for infants and children over two years of age.

Transparency

Dusting Analysis

Not commonly dusted

Hydrocortisone Acetate is an FDA-approved drug, used therapeutically at specified concentrations ranging from 0.5% to 2.5% for medical skin conditions. It is not typically 'dusted' in cosmetic formulations due to its potent therapeutic nature and regulated dosage requirements for efficacy and safety.

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

Hydrocortisone acetate is generally stable under normal conditions but can be sensitive to light and moisture. Optimal stability is maintained within a pH range of 4.5 to 7.0 to prevent hydrolysis. Liquid formulations may require storage at 0-6°C, while solid forms should be kept in dry, dark conditions. Stabilizers like methylparaben can help prevent degradation.

Conflicts

  • Strong oxidizing agents
  • Active fungal, bacterial, or viral infections of the skin

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2.5%
Pregnancy
Caution
Sensitization risk Unknown

Hydrocortisone Acetate is an FDA-approved drug, available over-the-counter at 0.5% and 1% concentrations, and by prescription at higher concentrations like 2.5%. Safety data sheets indicate it is 'Suspected of damaging fertility or the unborn child' in concentrated forms. It is for external use only, with contact with eyes to be avoided. Prolonged use, application over large surface areas, or use under occlusive dressings can increase systemic absorption, potentially leading to hypothalamic-pituitary-adrenal (HPA) axis suppression and skin atrophy. It is generally not recommended for use in children under two years of age and is contraindicated in the presence of active bacterial, fungal, or viral skin infections.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydrocortisone Acetate is a highly effective corticosteroid, providing valuable anti-inflammatory and soothing benefits for the precise management of specific inflammatory skin conditions.

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