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Moumoujus

HUMAN UMBILICAL EXTRACT.

Avoid CAS - / NOT REPORTED

Human Umbilical Extract, derived from the umbilical cord, is a rich source of beneficial components like growth factors, proteins, and antioxidants. It is studied for its potential to stimulate skin cell renewal, promote collagen production, and offer anti-inflammatory and barrier-strengthening effects.

Summary

Antioxidant Humectant Skin Protecting Collagen Boosting Anti-inflammatory Wound Healing Support Cell Proliferation Enhancer Skin Barrier Support Solvent

Science

Mechanism of Action

This extract primarily functions through mesenchymal stem cell-derived components, such as conditioned media and extracellular vesicles. It actively promotes collagen synthesis, reduces oxidative stress by neutralizing reactive oxygen species, and accelerates tissue repair for improved wound healing. Additionally, it possesses anti-inflammatory properties by decreasing inflammatory cytokines like TNF-α and IL-6, supports cell proliferation and new blood vessel formation (angiogenesis), and enhances skin barrier function. Its rich composition includes enzymes, hormones, antioxidants, vitamins, amino acids, and minerals, which collectively contribute to its protective effects against UV, H2O2 damage, and Advanced Glycation End-Products (AGEs).

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An in vitro study demonstrated that a 7.5% concentration was most effective in stimulating fibroblast and keratinocyte proliferation, inducing collagen expression, and inhibiting matrix metalloproteinase-1 (MMP-1) at the transcriptional level.
  2. 02 Conditioned media derived from umbilical cord blood mesenchymal stem cells (UCB-MSC-CM) significantly improved skin barrier function and reduced inflammatory responses in patients with sensitive skin in a clinical trial.
  3. 03 Field trials involving approximately 2500 users over 36 months reported no instances of skin irritability or adverse interactions from products containing human umbilical extract.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for the stability of Human Umbilical Extract in cosmetic formulations was found. However, the stability of its protein components is generally correlated with their optimal activity pH, with physiological blood pH (7.36-7.44) and embryo culture media (7.2-7.4) suggesting stability around this neutral-to-slightly alkaline range.

Conflicts

  • Prohibited for cosmetic use in the European Union due to significant concerns regarding the potential transmission of human spongiform encephalopathies and various viral diseases (e.g., HIV).
  • Requires stringent pre-testing for microbial and fungal contamination, and mandatory screening of the source mother's blood for infectious viral agents.
  • The FDA may not recognize certain human placental or umbilical extracts as cosmetic ingredients if they are believed to contain estrogenic hormones or other biologically active substances.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

As of 2010, the Cosmetic Ingredient Review (CIR) categorized Human Umbilical Extract as a 'Zero use ingredient with Insufficient Data'. This ingredient faces major regulatory hurdles, being explicitly prohibited from cosmetic use under the European Union's cosmetics directive due to serious concerns about the transmission of human spongiform encephalopathies and viral diseases. The FDA also has reservations about recognizing it as a cosmetic ingredient if it is assumed to contain estrogenic hormones or other biologically active substances. While FDA 510(k) clearance exists for human umbilical cord-derived *medical devices* for wound care, this does not apply to cosmetic applications. Rigorous screening for pathogens (microbial, fungal, viral) is essential if used.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite promising in vitro and some clinical data on skin benefits, the severe regulatory restrictions, outright prohibition in the EU, and significant safety concerns regarding potential disease transmission render Human Umbilical Extract unsuitable for cosmetic formulation.

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