Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HUMAN PERIPHERAL BLOOD DERIVED NATURAL KILLER CELL CONDITIONED MEDIA.

Valuable / SKIN CONDITIONING, SKIN PROTECTING

Human Peripheral Blood Derived Natural Killer Cell Conditioned Media (NK-CdM) is a biotechnologically derived complex of bioactive factors secreted by Natural Killer cells. It is engineered to deliver a broad spectrum of cytokines, growth factors, and anti-inflammatory agents to the skin, promoting advanced regeneration and protection.

Summary

Skin Conditioning Skin Protecting Anti-aging Antioxidant Wound Healing Barrier Support Collagen Synthesis Promoter

Science

Mechanism of Action

Rich in various bioactive cytokines (e.g., IL-1β, IL-6, TNFα, TGFβ, IFNγ) and growth factors (e.g., IGF-1, PDGF), NK-CdM operates through multiple pathways to enhance skin health. It supports wound healing and wrinkle reduction by facilitating epithelial-mesenchymal transition, upregulating kallikreins, and downregulating matrix metalloproteinase-1 and -2. The conditioned media actively combats photoaging by mitigating UVB-induced cytotoxicity, suppressing reactive oxygen species (ROS) production, and boosting antioxidant enzyme expression, including SOD1 and catalase. Furthermore, it reinforces the epidermal skin barrier and hydration by preventing the UVB-induced depletion of filaggrin and involucrin, and by maintaining levels of hyaluronan synthases, aquaporin-3, and hyaluronan. NK-CdM also stimulates dermal fibroblast proliferation, enhances procollagen synthesis, and inhibits collagen degradation by inactivating MAPK signaling.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–20%
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrate no significant cytotoxicity in HaCaT keratinocytes at concentrations up to 20%.
  2. 02 Promotes cell migration, up-regulates kallikreins (KLKs), and down-regulates MMP-1 and MMP-2, indicating potential for wound healing, skin regeneration, and anti-aging.
  3. 03 Mitigates UVB-induced cellular damage, suppresses reactive oxygen species (ROS) production, and enhances the expression of antioxidant enzymes (SOD1, CAT) in human keratinocytes and a reconstructed skin model.
  4. 04 Prevents the UVB-induced reduction of filaggrin, involucrin, hyaluronan synthases (HAS1, HAS2, HAS3), aquaporin-3, and hyaluronan levels, supporting skin barrier integrity and hydration.
  5. 05 Induces proliferation of UV-B-treated human dermal fibroblasts, increases procollagen expression, decreases MMP-1 expression, and inhibits UV-B-induced collagen degradation by inactivating MAPK signaling.

Transparency

Dusting Analysis

Not commonly dusted

Current research does not indicate widespread 'dusting' practices for this novel ingredient, nor is there a defined minimum effective percentage beyond the noted non-cytotoxic range.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a biological conditioned medium rich in sensitive bioactive components, NK-CdM is likely susceptible to degradation by extreme temperatures, pH fluctuations, and oxidation. Specific stability data, including an optimal pH range, are not explicitly available in the current research.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
20%
Sensitization risk Unknown

An in vitro study found no significant cytotoxicity in human keratinocytes at concentrations below 20%. It is important to note that while FDA clearance exists for NK cell therapies for cancer treatment, this regulatory status does not directly extend to NK-CdM as a cosmetic ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Human Peripheral Blood Derived Natural Killer Cell Conditioned Media shows significant promise in advanced skin regeneration, anti-aging, and protective functions, supported by robust in vitro and ex vivo data, pending further human clinical validation.

Related

Similar Ingredients

Finding similar ingredients…