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Moumoujus

HUMAN BLOOD LYMPHOCYTE CONDITIONED MEDIA.

Avoid / BLEACHING, SKIN PROTECTING

Human Blood Lymphocyte Conditioned Media is a biological extract, primarily derived from Regulatory T cells, that shows potential for stimulating skin regeneration and repair. It is investigated for its capacity to enhance wound healing, promote cellular turnover, and improve overall skin texture and firmness.

Summary

Skin protecting Bleaching Anti-inflammatory Skin regeneration Collagen stimulation Elastin fiber growth Dermal cell turnover Skin firming Wound healing

Science

Mechanism of Action

This ingredient, specifically from Regulatory T (Treg) cells, promotes wound healing by stimulating HaCaT keratinocyte migration. It achieves this by inducing Epithelial-Mesenchymal Transition (EMT) and down-regulating E-cadherin at the wound edge. Furthermore, it increases Matrix Metalloproteinase-1 (MMP-1), crucial for tissue remodeling and extracellular matrix degradation. The media is also reported to possess anti-inflammatory effects, aid in the recovery of damaged skin cells, stimulate collagen and elastin production, and enhance dermal cell turnover for firmer skin.

Research

Clinical Evidence

Medium confidence
Effective range 1–5%
Optimal

N/A

Key findings

  1. 01 Increased HaCaT keratinocyte migration.
  2. 02 Increased HaCaT keratinocyte migration.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6.9 – 7.4
0 7 14

Stability

Optimal stability is observed around physiological pH, specifically within the 6.9 to 7.4 range, which aligns with the intracellular pH maintained by quiescent human peripheral blood lymphocytes. As a complex mixture of biomolecules, its stability can be compromised by exposure to heat or extreme pH variations.

Conflicts

  • Prohibited for use in cosmetic formulations in the EU.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

HUMAN BLOOD LYMPHOCYTE CONDITIONED MEDIA is explicitly prohibited as a cosmetic ingredient in the European Union under restriction II/416. Similarly, Human Cord Blood Cell Conditioned Media is also regulated and forbidden in Europe. The FDA categorizes this as a cell-based product, requiring specific safety testing as per guidance for allogeneic cell-based medical products, but no specific 'safe as used' cosmetic status has been identified.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite promising preclinical data on skin regeneration and repair, this ingredient is strictly prohibited in cosmetic products within the European Union, and its safety status for cosmetic use by the FDA remains unestablished, making it unsuitable for Moumoujus formulations.

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