Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HORNET EXTRACT.

Avoid / ANTI-SEBUM, ANTIMICROBIAL, SKIN CONDITIONING, SKIN PROTECTING

Hornet Extract encompasses substances derived from hornets, including larval and venom sac components, studied for their potential bioactivities in skincare. Research indicates properties such as antioxidant, anti-inflammatory, and wound healing, though data primarily stems from in vitro and animal models.

Summary

Antioxidant Anti-inflammatory Wound Healing Skin Conditioning Skin Protecting Antimicrobial Antiseborrhoeic

Science

Mechanism of Action

This ingredient functions through multiple proposed mechanisms: hornet larval extracts demonstrate antioxidant effects by upregulating enzymes like GST and CAT, and exhibit anti-inflammatory capabilities. Certain larval extracts have also shown anti-migratory activity in specific cancer cell lines. Oriental hornet venom sac extract (VSE) has been observed to enhance wound healing, potentially via its collagenolytic action. CosIng categorizes it for cosmetic applications including antimicrobial, antiseborrhoeic, skin conditioning, and skin protecting functions.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Oriental hornet larval aqueous extract demonstrated no cytotoxic effects on normal Vero cells at concentrations up to 100 µg/mL; a minor 1% cell viability inhibition was noted at 200 µg/mL in vitro.
  2. 02 Both aqueous and alcoholic extracts of Oriental hornet larvae significantly inhibited MCF7 (breast cancer) cell migration in vitro.
  3. 03 Topical application of Oriental hornet venom sac extract to rat skin promoted wound healing and repair, potentially linked to its collagenolytic activity.
  4. 04 An aqueous extract from the lesser banded hornet showed antioxidant effects by activating antioxidant enzymes (GST and CAT) in vitro.

Transparency

Dusting Analysis

Not commonly dusted

No information is available to suggest this ingredient is commonly dusted or requires a dusting analysis for topical application.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Studies utilizing both aqueous and alcoholic extracts of hornet larvae indicate solubility in both water and alcohol. Specific optimal pH ranges for stability in cosmetic formulations are not documented. General topical products are typically formulated within a pH range of 4 to 6 for optimal skin compatibility.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Hornet Extract has not been reviewed for safety by the Cosmetic Ingredient Review (CIR) or SCCS, and no maximum safe concentrations for cosmetic use have been established. It is critical to note that hornet venom extracts are known to induce severe systemic allergic reactions in humans and are strictly regulated in medical allergy immunotherapy. Although larval extracts are distinct from venom, the general term 'Hornet Extract' carries a substantial risk of severe allergic responses due to potential residual venom components or cross-reactivity. Dermal toxicity is largely undetermined, presenting a significant safety concern for cosmetic product integration.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the critical lack of comprehensive safety data for topical cosmetic use, the well-documented severe allergic potential associated with hornet venom, and the absence of established safe concentration limits, Hornet Extract is strongly advised against for skincare formulations.

Related

Similar Ingredients

Finding similar ingredients…