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Moumoujus

HIBISCUS CANNABINUS EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Hibiscus Cannabinus Extract, derived from the Kenaf plant, is a multi-functional botanical ingredient. It provides comprehensive benefits for skin health, encompassing significant antioxidant, anti-inflammatory, anti-aging, and skin brightening properties. Its versatile nature makes it an excellent addition across a wide spectrum of precision skincare formulations.

Summary

Antioxidant Anti-inflammatory Skin Brightening Anti-aging Wrinkle Reduction Barrier Support UV Protection (supportive) Soothing

Science

Mechanism of Action

This extract functions as a potent natural antioxidant, demonstrating strong DPPH free radical scavenging capacity and reducing intracellular reactive oxygen species (ROS) production. It exerts anti-inflammatory effects by decreasing the mRNA expression of various inflammatory cytokines (e.g., IL-1β, IL-4, IL-6, IL-8, IL-13) and down-regulating NF-κB and MAPKs activation, while also inhibiting the NLRP-3 inflammasome. Furthermore, it supports skin barrier restoration through enhanced synthesis of filaggrin and involucrin proteins. For anti-hyperpigmentation, it inhibits skin tyrosinase activity and melanin production in B16 cells. Its anti-aging properties are attributed to inhibiting collagenase, elastase, skin lipoxygenase, COX, MMP-1, and MMP-3 activities, alongside promoting collagen secretion.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–20%
Optimal

N/A

Key findings

  1. 01 Clinical application in this range demonstrated potential for wrinkle reduction, skin whitening, sunscreen effects, and overall skin care. Compositions were found to inhibit skin tyrosinase activity, B16 cell melanin production, elastin activity, TNF-α secretion, and skin oxidation, while promoting collagen secretion. Inhibition of skin lipoxygenase, COX, MMP-1, and MMP-3 activity was also observed, proving effective for fine lines/wrinkles, skin rashes, dry/sensitive/itchy skin, uneven skin tone/dark spots, and skin inflammation.
  2. 02 This specific formulation showcased antioxidant, antityrosinase, and anti-aging benefits through the inhibition of collagenase and elastase. It also highly suppressed cellular tyrosinase activity and melanin content in B16F10 cells.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that Hibiscus Cannabinus Extract is commonly 'dusted' or used at sub-efficacious concentrations for marketing purposes. Efficacious concentrations range from 0.001% to 20.0%.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract's versatility allows for dissolution in various solvents including water, alcohols (methanol, ethanol, propanol, butanol), glycol, and oil, depending on the desired active compounds and extract type. Kenaf seed oil, often co-extracted or co-formulated, can enhance the stability of vitamin E in cosmetic formulations.

Synergies

  • Vitamin E (improved stability when co-formulated with Kenaf seed oil)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Hibiscus cannabinus oil demonstrated no toxicity up to 5000 mg/kg body weight in oral acute toxicity tests in rats. Ethanol extracts of kenaf root and all extracts of leaves and seeds were observed as non-toxic in NIH3T3 cell studies, indicating a generally good safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Hibiscus Cannabinus Extract is a valuable, multi-faceted botanical ingredient offering comprehensive benefits from antioxidant and anti-inflammatory action to anti-aging and skin brightening, making it highly suitable for all skin types in precision skincare formulations.

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