Science
Mechanism of Action
The primary mechanism of HEXAHYDRO-TETRAMETHYL-METHANOAZULEN-5-YL METHYL KETONE is to impart a scent profile; direct skincare benefits have not been established. Chemically, it is an unsaturated ketone with a bridged ring structure. The external ketone carbonyl group can participate in condensation reactions, forming imine derivatives with organic amine compounds.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient exhibits stability in various product bases, including acid cleaners, alcoholic lotions, detergents, fabric softeners, and shampoos. For optimal longevity, storage in tightly sealed containers in a cool, dry place, protected from heat and light, is recommended, ensuring a shelf life of 24 months or more.
Conflicts
- strong acids
- alkali
- oxidizing agents
Safety
Safety Profile
Evaluated by the Research Institute for Fragrance Materials (RIFM), this ingredient (also known as Acetyl Cedrene) is deemed safe for use as a fragrance component. Assessments included genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, and skin sensitization. It is identified as a skin sensitizer, with a defined No-Effect Sensitization Induction Level (NESIL) of 35000 µg/cm². The Scientific Committee on Consumer Safety (SCCS) has noted restrictions for its use in cosmetic products, indicating safety only under specific conditions (e.g., purity, maximum concentration, or specific product categories). In California's Safe Cosmetics Program, it requires reporting for leave-on products at or above 0.001% (10 ppm) and for rinse-off products at or above 0.01% (100 ppm). RIFM suggests usage levels up to 20.0% in fragrance concentrates, with reported dermal exposures in hydroalcoholic products ranging from 0.002% to 15.16%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient primarily serves as a fragrance without offering direct skincare benefits. Its classification as a skin sensitizer and regulatory restrictions raise concerns for precision skincare formulations, despite its widespread use.
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