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Moumoujus

HETEROTHECA INULOIDES FLOWER EXTRACT.

Valuable CAS 90045-70-8 / FRAGRANCE

Heterotheca Inuloides Flower Extract is a botanical active renowned for its multifaceted dermatological benefits. Rich in flavonoids, it offers significant antioxidant protection, calms inflammation, and contributes to a more even skin tone through tyrosinase inhibition. This extract is derived from a flower known for its soothing and regenerative properties.

Summary

Antioxidant Anti-inflammatory Skin Brightening Soothing Masking

Science

Mechanism of Action

This extract exerts anti-inflammatory effects by attenuating responses to various inflammatory triggers, including carrageenan, dextran, and arachidonic acid, and exhibits analgesic properties. Its robust antioxidant capacity is driven by compounds like quercetin, kaempferol, luteolin, apigenin, and cadinane type sesquiterpenes, which efficiently scavenge reactive oxygen species such as singlet oxygen, hydroxyl radicals, and DPPH. Furthermore, specific flavonoids within the extract demonstrate tyrosinase inhibition, a key mechanism for reducing hyperpigmentation and promoting skin brightening by inhibiting melanin production.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An aqueous extract produced a 29% inhibition of inflammation in a carrageenan-induced edema test in mice, at a concentration of 100 mg/kg i.p.
  2. 02 A butanol fraction (HI-2) showed an ED50 of 29.7 mg/kg i.p. for anti-inflammatory activity against carrageenan-induced edema. It also inhibited inflammation induced by dextran (38.9-68.1% inhibition at 50-100 mg/kg i.p.) and arachidonic acid (0-33.9% inhibition at 50-100 mg/kg i.p.), alongside reducing abdominal constrictions (73.8-78.2% inhibition at 50-100 mg/kg i.p.).
  3. 03 Flavonoids (quercetin, kaempferol, luteolin, apigenin) from the flower extract inhibited tyrosinase, suggesting skin brightening properties. These compounds also inhibited lipid peroxidation and scavenged DPPH radical, confirming robust antioxidant activity.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to assess common dusting practices or thresholds for this specific extract.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

An in vitro assay for singlet oxygen scavenging was conducted at pH 7.1. A general optimal pH range for stability in broader cosmetic formulations is not explicitly defined in the available research.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel has not issued a specific 'safe as used' conclusion due to insufficient data for Heterotheca Inuloides Flower Extract. While the FDA Global Substance Registration System lists it as a plant extract used in some OTC products, it is not an approved drug. Ingredients from the Compositae family, to which Heterotheca inuloides belongs, are recognized as potential sensitizers, necessitating careful formulation to mitigate any sensitization risk.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Heterotheca Inuloides Flower Extract offers valuable antioxidant, anti-inflammatory, and skin brightening benefits, though its safety profile requires careful consideration due to insufficient CIR data and potential sensitization risk associated with its plant family.

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