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Moumoujus

HEPTAPEPTIDE-43.

Insufficient Data / NOT REPORTED

HEPTAPEPTIDE-43 is a specialized peptide demonstrating initial promise in protecting skin from ultraviolet radiation-induced damage. When formulated in a delivery system, a specific heptapeptide significantly reduces DNA damage following UVA exposure, contributing to its potential anti-aging effects. Further research is needed to fully characterize this specific ingredient.

Summary

UV damage protection DNA damage reduction Anti-aging Skin conditioning

Science

Mechanism of Action

No direct mechanism of action specifically identified for HEPTAPEPTIDE-43 was found in the available research. However, the amorphous heptapeptide (DEETGEF) referenced in clinical studies appears to exert its protective effects by directly mitigating cellular damage induced by UV radiation. Broader research on other heptapeptides indicates diverse functions, including promoting cell growth, stimulating collagen synthesis, reducing muscle contractions for wrinkle smoothing, and acting as targeting agents for other actives.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

0.014%

Transparency

Dusting Analysis

Not commonly dusted

There is no specific data available regarding 'dusting' or common misuse concentrations for HEPTAPEPTIDE-43 in the provided research.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Specific optimal pH and stability data for HEPTAPEPTIDE-43 are not detailed. General peptide stability is highly pH-dependent; some peptides exhibit optimal stability at acidic pH, such as pH 4.5. Solubility is sequence-specific; hydrophilic peptides are typically water-soluble, while hydrophobic ones may require organic solvents or specialized delivery systems like solid lipid nanoparticles to be dispersed in both lipid and aqueous phases. Peptides containing Cys, Met, or Trp are prone to oxidation and may necessitate oxygen-free solvents or polyol excipients to enhance stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

HEPTAPEPTIDE-43 has not undergone specific safety evaluations by regulatory bodies such as CIR, SCCS, or FDA. While the Cosmetic Ingredient Review (CIR) Expert Panel has assessed other peptides, concluding their safety at typical low cosmetic concentrations (e.g., less than 10 ppm), these findings do not directly pertain to HEPTAPEPTIDE-43. Therefore, comprehensive safety data specific to this ingredient is currently unavailable.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

HEPTAPEPTIDE-43 presents promising initial data for UV protection and DNA damage reduction; however, a lack of specific mechanism of action, comprehensive safety data, and broader clinical validation for this named ingredient currently limits a full evaluation of its wider cosmetic utility.

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