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Moumoujus

HEPTAPEPTIDE-39.

Valuable / SKIN CONDITIONING

Heptapeptide-39 is a precision peptide engineered to target the appearance of visible cellulite. It functions by modulating specific cellular pathways to reduce lipid accumulation, thereby contributing to smoother skin texture and improved dermo-hypodermal junction regularity.

Summary

Anti-cellulite Adipogenesis inhibition Skin smoothing

Science

Mechanism of Action

This peptide, specifically Acetyl Hexapeptide-39 in clinical contexts, acts by decreasing PCG-1α expression. This reduction subsequently diminishes preadipocyte differentiation and restricts lipid accumulation within adipose tissue, directly addressing the underlying causes of visible cellulite and smoothing irregularities at the dermo-hypodermal junction.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–0.005%
Optimal

N/A

Key findings

  1. 01 Clinical studies utilizing Acetyl Hexapeptide-39 at concentrations between 0.001% and 0.005% demonstrated a reduction in adipogenesis, leading to an improvement in the appearance of visible cellulite and a smoothing effect on dermo-hypodermal junction irregularities.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 7
0 7 14

Stability

Optimal stability for Acetyl Hexapeptide-39 is maintained within a pH range of 5.0 to 7.0. It should be integrated into formulations during the final phase, ensuring the temperature remains below 45 °C to preserve its integrity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific regulatory assessments by CIR, SCCS, or FDA for Heptapeptide-39 or Acetyl Hexapeptide-39 are not available. General peptide safety evaluations by the CIR panel suggest topical concentrations below 10 ppm are typically safe. However, caution is advised for elastin-derivative peptides, when combined with other active ingredients, or when applied to compromised skin.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Heptapeptide-39 offers a valuable, targeted approach to reduce the appearance of visible cellulite by precisely inhibiting adipogenesis.

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