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Moumoujus

HEMATIN.

Insufficient Data CAS 15489-90-4 / HAIR CONDITIONING

Hematin is an iron-containing porphyrin compound, a derivative of heme, observed to play a role in biological pigmentation. In cosmetic applications, it is primarily suggested for its potential to support hair pigmentation and improve the appearance of gray hair, hinting at a role in melanin synthesis.

Summary

Pigmentation Support Hair Follicle Health

Science

Mechanism of Action

This heme derivative is integral to heme metabolism, influencing heme proteins, oxygen transport, and cytochrome systems. Within cosmetic science, its proposed mechanism involves enhancing melanin synthesis or promoting overall hair follicle health, leveraging its inherent biochemical activity and pigmentation properties to support natural hair color.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 4.8 – 7.6
0 7 14

Stability

Hematin exhibits light sensitivity and is prone to rapid degradation when reconstituted with sterile water. Optimal solubility for crystallization has been observed in the pH range of 4.8 to 7.6, with significantly enhanced solubility in organic solvents (e.g., water-saturated octanol) compared to aqueous solutions at pH 4.8, indicating specific solvent selection is crucial for formulation integrity.

Conflicts

  • Rapid degradation in sterile water
  • Light exposure

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While hematin is used therapeutically for acute porphyrias and generally well-tolerated intravenously at FDA-approved doses, there is no dedicated Cosmetic Ingredient Review (CIR) assessment or Scientific Committee on Consumer Safety (SCCS) opinion available for its topical cosmetic application. Its rapid degradation in sterile water also presents a significant formulation stability challenge.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Hematin shows promising theoretical applications for hair pigmentation, but comprehensive data on its efficacy and safety for broad topical skincare use remains insufficient.

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References

Sources