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Moumoujus

HDI ISOCYANURATE TRIMER.

Avoid CAS 3779-63-3 / NOT REPORTED

HDI Isocyanurate Trimer is a polyisocyanate derived from hexamethylene diisocyanate (HDI). In cosmetic applications, it functions primarily as a film-forming agent, creating a continuous, protective film on the skin's surface.

Summary

Film-forming

Science

Mechanism of Action

This ingredient operates by forming a stable, three-dimensional cross-linked polyurethane network. It achieves this through its three reactive isocyanate groups, which readily react with polyols or other active hydrogen-containing compounds present in a formulation. On the skin, this reaction creates a continuous, durable film, providing a protective barrier or enhancing the texture and feel of the product.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

HDI Isocyanurate Trimer contains highly reactive isocyanate (-NCO) groups, making it susceptible to reaction with water, alcohols, acids, and amines. It can also decompose upon exposure to alkalis, and polymerization may occur in the presence of copper, iron, or other metal oxides. Optimal stability necessitates storage in a tightly closed, dry, cool, and well-ventilated environment, away from incompatible materials. Its high lipophilicity (log Pow of 9.81) confirms its oil-solubility and general insolubility in cold water.

Conflicts

  • water
  • alcohols
  • acids
  • amines
  • alkalis
  • copper
  • iron
  • metal oxides

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Panel has noted 'insufficient data' for certain HDI polymers, including those related to this trimer, particularly regarding molecular weight and solubility to assess skin penetration. A significant safety concern for HDI polymers, and diisocyanates generally, is the potential release of monomeric HDI, which is a known respiratory and skin sensitizer and irritant. The raw material's Safety Data Sheet (SDS) classifies Hexamethylene diisocyanate isocyanurate trimer as 'Skin sensitization, Category 1,' indicating it 'May cause an allergic skin reaction,' and also cites 'Acute toxicity - Category 4, Inhalation' and 'Specific target organ toxicity – single exposure, Category 3' (May cause respiratory irritation).

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Low

Our Assessment

Verdict

Avoid

Due to insufficient safety data from the CIR Panel regarding skin penetration and the raw material's classification as a Category 1 skin sensitizer, HDI Isocyanurate Trimer presents an unacceptable risk for precision skincare formulations.

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