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HC YELLOW NO. 13.

Avoid CAS 10442-83-8 / HAIR DYEING

HC Yellow No. 13 is a direct synthetic dye primarily employed in hair color formulations to impart a yellow hue. It functions by adhering to the hair surface without a chemical reaction with other ingredients.

Summary

Hair dyeing

Science

Mechanism of Action

This ingredient operates as a direct hair dye, physically attaching to the outermost layer of the hair shaft. This surface adhesion provides coloring without requiring an oxidative chemical reaction, making its mechanism specific to hair pigmentation.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Dermal exposure to HC Yellow No. 13 at 2.5% (w/w) was assessed for liver steatosis risk using in vitro assays and PBPK models, concluding it is unlikely to induce this effect under assumed conditions. No studies demonstrate direct efficacy for skin improvement.

Transparency

Dusting Analysis

Not commonly dusted

As an ingredient predominantly used in liquid or cream-based hair dye formulations, HC Yellow No. 13 is not typically encountered or 'dusted' in powder form within cosmetic or skincare manufacturing processes.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Initially, the stability of HC Yellow No. 13 in typical hair dye formulations was a concern. However, subsequent evaluations demonstrated stability for up to 45 minutes in hair dye formulations containing hydrogen peroxide. Its water solubility is reported as 506 mg/L at 20°C.

Conflicts

  • Nitrosating agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Reviewed by the SCCS and considered safe for use in cosmetic products, including a maximum concentration of 5.0% in oxidative hair dye formulations (2.5% in-use after mixing) and color setting lotions. As a secondary alkanolamine, it is susceptible to nitrosation and must not contain more than 50 ppb nitrosamine, nor be used with nitrosating agents. Significant concerns arise from its classification as a per- and polyfluoroalkyl substance (PFAS), indicating potential for enhanced skin absorption, moderate endocrine disruption, high persistence, bioaccumulation, and moderate non-reproductive organ system toxicity. Animal studies showed low acute oral and dermal toxicity, no signs of eye or skin irritation, and negative sensitization. However, an in vitro mammalian chromosomal aberration test yielded a positive result for clastogenicity.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its approved use in hair colorants, HC Yellow No. 13 is classified as a PFAS with associated concerns regarding endocrine disruption, persistence, and bioaccumulation, coupled with an in vitro positive clastogenicity finding, rendering it unsuitable for precision skincare formulations.

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