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HALOCIDIN SUBUNIT A AMIDE/HALOCIDIN SUBUNIT B AMIDE.

Insufficient Data / SKIN PROTECTING

Halocidin Subunit A Amide/Halocidin Subunit B Amide is a synthetic antimicrobial peptide (AMP) derived from the marine halocidin family. It functions primarily by disrupting microbial cell membranes, offering broad-spectrum activity against various pathogens, and also contributes to host immune response modulation.

Summary

Antimicrobial Antifungal Immune Modulator

Science

Mechanism of Action

This peptide primarily operates by compromising the structural integrity of microbial membranes, leading to rapid cellular lysis and death. For fungi, it specifically interacts with beta-1,3-glucan on the cell surface, inducing the formation of ion channels within the membrane, which ultimately causes cell demise. Beyond direct antimicrobial action, it can enhance host immune responses by modulating innate and adaptive immunity, facilitating the recruitment and activation of immune cells, and influencing cytokine networks, thereby supporting tissue protection and repair mechanisms. A notable halocidin derivative, HG1, demonstrates resistance to proteolytic degradation by enzymes like trypsin, chymotrypsin, and human matrix metalloprotease 7 (MMP-7), indicating stability in complex biological fluids such as human skin wound fluid.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 The synthetic halocidin analogue di-K19Hc exhibited potent antifungal activity, inhibiting Candida albicans at concentrations below 4 µg/ml.
  2. 02 The synthetic halocidin analogue di-K19Hc demonstrated antifungal activity against Aspergillus species at concentrations below 16 µg/ml.
  3. 03 Antimicrobial activity of di-K19Hc was observed against antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa, in radial diffusion assays.

Transparency

Dusting Analysis

Not commonly dusted

This ingredient is not commonly found in mainstream cosmetic products, with current research primarily focusing on its pharmaceutical potential as an antimicrobial and antifungal agent. Its presence in cosmetic formulations is not yet widespread enough for 'dusting' practices to be relevant.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

A halocidin-derived peptide, HG1, has demonstrated resistance to proteolytic degradation by enzymes such as trypsin, chymotrypsin, and human matrix metalloprotease 7 (MMP-7), indicating potential stability in biological environments. It maintains strong antimicrobial potency at a pH of 7.4. The presence of TFA salts, common byproducts of peptide purification, generally enhances its solubility in aqueous solutions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

This ingredient, or 'Halocidin' in general, lacks formal review by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) for cosmetic applications. The FDA has not issued a specific status for Halocidin as a cosmetic ingredient. While native halocidin monomers and dimers have shown mild hemolytic activity against human red blood cells, a specific synthetic analogue (di-K19Hc) exhibited significantly reduced hemolytic potential. The safety profile for cosmetic use remains largely uncharacterized.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Halocidin Subunit A Amide/Halocidin Subunit B Amide shows promising broad-spectrum antimicrobial activity; however, comprehensive safety and efficacy data for its use in precision skincare remain to be established.

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