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Moumoujus

GUAZUMA ULMIFOLIA EXTRACT.

Insufficient Data CAS - / SKIN PROTECTING

Derived from the leaves, bark, and fruit of the Guazuma ulmifolia plant, this extract is recognized for its traditional use in skin health. It is characterized by a rich phytochemical profile, endowing it with antioxidant, anti-inflammatory, and antimicrobial properties that contribute to skin conditioning and protection.

Summary

Skin Protecting Skin Conditioning Antioxidant Anti-inflammatory Antimicrobial

Science

Mechanism of Action

Guazuma Ulmifolia Extract exerts its effects through a complex blend of phytochemicals including alkaloids, tannins, saponins, flavonoids, terpenoids, and steroids. Its antioxidant capacity is primarily attributed to phenolic compounds like flavonoids and tannins, which function via radical-scavenging mechanisms. The extract's anti-inflammatory properties have been observed, and its antimicrobial activity, effective against various bacteria and fungi, underpins its traditional application for maintaining skin health and reducing irritation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies showed methanol extract from Guazuma ulmifolia leaves inhibited *Staphylococcus aureus* bacteria with inhibition zones up to 12.31 mm at 100% concentration, and *Klebsiella pneumoniae* with inhibition zones up to 14.27 mm at 100% concentration.
  2. 02 In vitro antibacterial activity was demonstrated by bark, leaf, and fruit extracts against a range of bacteria including *S. aureus*, *B. cereus*, *E. coli*, and *P. aeruginosa*, with ethanolic extracts of bark showing the most pronounced activity.
  3. 03 Ethanolic extracts from the bark and fruit exhibited in vitro antifungal activity against *Cladosporium cucumerinum* and *Penicillium oxalicum*.

Transparency

Dusting Analysis

Not commonly dusted

Data regarding common 'dusting' practices or thresholds for this ingredient is not available in the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Studies on dried extracts indicate that procyanidin B2 (PB2) content remains stable over 21 days at 45°C and 75% relative humidity. However, epicatechin (EP) content in dried extracts combined with colloidal silicon dioxide demonstrated significant changes. A general optimal pH range for formulation stability is not specified.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments from CIR or SCCS are readily available, and FDA status for cosmetic use is not explicitly reviewed. While INCIDecoder suggests low irritancy, overall dermal toxicity and sensitization risk remain undetermined. Animal studies indicate potential uterine stimulant activity, which suggests caution for internal use, especially during pregnancy. Robust scientific validation for its effectiveness and safety in human skin health is largely lacking, with most evidence derived from in vitro, animal research, and traditional usage.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While exhibiting promising in vitro antioxidant, anti-inflammatory, and antimicrobial properties, Guazuma Ulmifolia Extract lacks robust human clinical data for comprehensive efficacy and safety in topical skincare applications, necessitating further investigation for precision cosmetic use.

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