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Moumoujus

GUAIACUM OFFICINALE WOOD OIL.

Insufficient Data CAS 84650-13-5 / FLAVOURING, FRAGRANCE, PERFUMING

Guaiacum officinale wood oil is a botanical extract characterized by its semi-solid to solid consistency at room temperature, offering notable anti-inflammatory and antioxidant properties for skin health. It is valued for its conditioning and protective attributes, contributing to overall skin vitality.

Summary

Fragrance Masking Skin Conditioning Antioxidant Anti-inflammatory Skin tightening Antiseptic Antimicrobial Wound healing Sebum control

Science

Mechanism of Action

This ingredient primarily acts as an anti-inflammatory agent by inhibiting the release of interferon gamma (IFNγ), a critical cytokine involved in the skin's inflammatory response. Concurrently, its rich antioxidant profile combats free radicals, mitigating oxidative stress and supporting anti-aging processes. Further benefits include mild skin tightening through tissue and blood vessel contraction, antiseptic and antimicrobial actions, enhancement of wound healing, and assistance in balancing sebum production to reduce both dryness and excessive oiliness.

Research

Clinical Evidence

Medium confidence
Effective range 1–50%
Optimal

10%

Key findings

  1. 01 An extract derived from guaiac wood has been shown to inhibit the release of interferon gamma (IFNγ), a key cytokine contributing to inflammatory processes in the skin, with optimal inhibition observed in the 10-30% concentration range.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Guaiacum officinale wood oil typically presents as a thick paste or semi-solid at ambient temperatures (around 20°C). It requires warming, ideally to 40-50°C, to liquefy for accurate measurement and incorporation into formulations. Once melted, it may remain in a supercooled liquid state for an extended period.

Conflicts

  • Strong oxidizing agents
  • Oxidizing mineral acids
  • Strong reducing agents

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Moderate

While the FDA has categorized Guaiac Wood Oil (FEMA 2534) as Generally Recognized As Safe (GRAS) for food flavoring, its safety for topical cosmetic applications is not definitively established by CIR or SCCS. Conflicting data exists, with some sources claiming it is non-irritating, non-sensitizing, and non-phototoxic, while others, notably Safety Data Sheets, caution about potential skin irritation and allergic reactions, advising protective measures. A patch test is recommended to assess individual sensitivity due to these discrepancies.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Guaiacum officinale wood oil exhibits promising anti-inflammatory and antioxidant properties for skin health; however, due to insufficient definitive safety data from regulatory bodies and conflicting reports on irritation potential, further research is required for its confident integration into precision skincare formulations.

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