Science
Mechanism of Action
The fermentation process amplifies the bioavailability and efficacy of key compounds from both Grifola frondosa and Panax ginseng, including polysaccharides, beta-glucans, and ginsenosides. Grifola frondosa acts as a functional antioxidant by mitigating reactive oxygen species (ROS) and inhibiting pro-inflammatory cytokine secretion, thus preventing cellular damage and inflammation. It also interferes with MAPK signaling pathways to calm skin inflammation, contributing to amelioration of conditions like atopic dermatitis, and inhibits tyrosinase for a brightening effect. Fermented Panax ginseng boosts skin metabolism, circulation, and provides robust antioxidant protection through its ginsenosides. Together, they promote skin hydration, barrier restoration, cell regeneration, and support a balanced skin microbiome, while reducing elastase, MMP-1, and MMP-9 activity to enhance collagen (COL-1) production and diminish wrinkle formation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 At 100 μg/mL, it significantly inhibited tyrosinase and melanin production in B16F10 cells, reducing tyrosinase, TYRP-1, and MITF mRNA expression. Demonstrated anti-wrinkle effects in UVB-irradiated human dermal fibroblasts by inhibiting elastase activity, decreasing MMP-1 and MMP-9, and elevating COL-1 mRNA expression. Also exhibited antioxidant activity by reducing ROS levels.
- 02 Blocked inflammasome-mediated caspase-1 activation and IL-1β secretion. Inhibited the production of reactive oxygen species and attenuated apoptosis-related proteins (Bax, Bcl-2, cleaved caspase-3) in normal human dermal fibroblasts (NHDFs) exposed to bisphenol A (BPA), preventing skin fibroblastic pyroptosis.
- 03 Ameliorated clinical symptoms in an AD-like mouse model, suppressing Th1, Th2, Th17, and Th22 immune responses in skin and spleen, protecting against cutaneous inflammation. In vitro, inhibited inflammatory cytokines by suppressing MAPK pathway activation in TNF-α/IFN-γ-stimulated keratinocytes.
Transparency
Dusting Analysis
No data available to suggest this ingredient is commonly dusted or to establish dusting thresholds.
The Formula
Formulation
Stability
The ferment filtrate is generally stable within a neutral to slightly acidic pH range. Related fermentation processes for red ginseng have been observed at a pH of 5.5, indicating optimal activity in slightly acidic conditions.
Synergies
- Other antioxidants
- Humectants
- Skin barrier strengthening ingredients
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Panel has not specifically reviewed 'GRIFOLA FRONDOSA /PANAX GINSENG EXTRACT FERMENT FILTRATE'. Related ingredients, such as unfermented Panax ginseng root extract, have shown no adverse effects in oral studies up to 20 mg/kg, and no carcinogenicity up to 5000 mg/kg. However, specific saponin components of ginseng have shown morphological changes in embryonic studies at 30-50 µg/ml. For 'yeast-derived ingredients', some ferment filtrates lacked sufficient CIR data for safety determination. Korean red ginseng extract is listed as GRAS by the FDA for certain food uses at 100-1000 mg/serving. The lack of specific CIR/SCCS data for this combined ferment filtrate means its sensitization risk is currently unknown, though component data suggests general good tolerance.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This fermented extract represents a valuable multi-functional ingredient, offering significant antioxidant, anti-inflammatory, and anti-aging benefits, making it suitable for a broad range of precision skincare applications despite the current lack of dedicated clinical studies on the exact combined ferment.
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