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Moumoujus

GLYOXYLOYL CYSTEINE.

Avoid / HAIR WAVING OR STRAIGHTENING

Glyoxyloyl Cysteine is an ingredient primarily associated with hair care, where it functions to temporarily modify keratin structure for straightening. While this profile is for Glyoxyloyl Cysteine, the available research data predominantly pertains to the closely related compound, Glyoxyloyl Carbocysteine, which shows no identified benefits for skin and presents significant safety concerns.

Summary

Science

Mechanism of Action

No specific mechanism of action on skin has been identified in the current literature. Its primary function, based on available data for Glyoxyloyl Carbocysteine, is in hair care, where it interacts with keratin to temporarily alter hair structure for straightening and smoothing.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted

Due to the absence of identified mechanisms of action or clinical benefits for skin, combined with significant safety concerns related to skin irritation and sensitization, its inclusion in skincare formulations without specific justification strongly suggests it may be a 'dusted' ingredient.

The Formula

Formulation

Solubility
Water
Optimal pH 1 – 2
0 7 14

Stability

This compound demonstrates optimal stability and activity within highly acidic environments, specifically at pH values ranging from 1.0 to 2.0.

Conflicts

  • Formulating products at its optimal pH range of 1.0-2.0 is extremely detrimental and irritating to skin, rendering it incompatible with healthy skin barrier function. Even in hair applications, such low pH can negatively impact scalp health.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

This ingredient, as Glyoxyloyl Carbocysteine, is categorized as a formaldehyde releaser. Its GHS classification identifies it as causing skin irritation (Skin Irrit. 2), potentially causing an allergic skin reaction (Skin Sens. 1), and causing serious eye damage (Eye Dam. 1). The Scientific Committee on Consumer Safety (SCCS) has raised concerns regarding potential renal toxicity associated with glyoxylic acid, a component of Glyoxyloyl Carbocysteine, particularly when used in hair straightening products involving high temperatures. The SCCS has not yet fully assessed its safety.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the complete absence of identified skin benefits, significant risks of skin irritation and sensitization, and an optimal pH range incompatible with healthy skin, this ingredient is strongly advised against for skincare formulations.

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