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Moumoujus

GLYOXYLOYL CARBOCYSTEINE.

Avoid CAS 1268868-51-4 / ANTISTATIC, HAIR WAVING OR STRAIGHTENING

Glyoxyloyl Carbocysteine is an amino acid derivative primarily utilized in haircare for its ability to modify hair structure, reducing curl and enhancing smoothness. Its mechanism of action is specifically targeted towards hair keratin and is typically activated by heat, with no direct efficacy demonstrated for skin.

Summary

Science

Mechanism of Action

This ingredient exclusively interacts with the keratin structure of hair, exhibiting no direct mechanism of action on skin. Its hair-modifying properties involve temporarily altering hair fiber bonds by breaking hydrogen and salt bonds and rearranging surface cystine bonds, a process facilitated by high heat (200-230°C). This results in the formation of new temporary bonds without affecting disulfide bonds, a mechanism not applicable to topical skin interaction.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Given its primary and well-documented action exclusively on hair, coupled with its significant safety warnings for skin irritation and sensitization, this ingredient is unlikely to be 'dusted' or deceptively included in precision skincare formulations for purported skin benefits.

The Formula

Formulation

Solubility
Water
Optimal pH 1 – 2.5
0 7 14

Stability

Optimal stability and performance are observed within highly acidic pH ranges, typically between pH 1.0 and 2.5. Maintaining this acidic environment is critical for preserving its structural integrity and preventing undesirable chemical transformations.

Conflicts

  • Application to irritated or compromised scalp due to increased risk of adverse effects from its high acidity.
  • Potential hair breakage if applied to hair with existing internal structural damage.
  • The extremely low optimal pH can increase adverse effects on both hair structure and scalp health if misapplied.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

This ingredient is classified as a 'Formaldehyde releaser' by INCI Beauty. PubChem indicates GHS hazard statements including 'Causes skin irritation' (H315), 'May cause an allergic skin reaction' (H317), and 'Causes serious eye damage' (H318). There is no specific FDA approval or status for Glyoxyloyl Carbocysteine as a cosmetic ingredient. Despite being discussed in the context of 'formaldehyde-free' hair straightening products, its classification as a formaldehyde releaser and noted irritancy are significant concerns for skin applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Glyoxyloyl Carbocysteine is an ingredient strictly for hair treatments, offering no known benefits for skin and posing significant risks due to its high irritancy, potential for allergic reactions, and classification as a formaldehyde releaser. It should be avoided in precision skincare formulations.

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