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Moumoujus

GLYCOL SALICYLATE.

Insufficient Data CAS 87-28-5 / UV ABSORBER

Glycol Salicylate is a salicylic acid ester primarily recognized for its anti-inflammatory and analgesic properties, frequently incorporated into topical pain relief products. It also presents potential utility in skincare formulations as a skin-conditioning agent, UV absorber, and fragrance component.

Summary

anti-inflammatory analgesic skin-conditioning UV absorber fragrance

Science

Mechanism of Action

This ingredient functions by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are critical for prostaglandin synthesis, thereby reducing pain and inflammatory responses. Its action also involves modulating inflammatory pathways via NF-κB inhibition and AMPK activation. Beyond these primary mechanisms, Glycol Salicylate is noted for counter-irritant effects, promoting keratin breakdown, inhibiting tyrosinase for melasma, and providing a degree of UV protection.

Research

Clinical Evidence

Low confidence
Effective range 1.4–5%
Optimal

5%

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding 'dusting' or common misuse at high concentrations for Glycol Salicylate in cosmetic applications was found in the provided research.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Glycol Salicylate maintains stability under typical conditions but requires protection from heat, sparks, ignition sources, and direct sunlight, with refrigeration suggested for prolonged storage. It is hygroscopic; heat and/or sonication may be necessary to aid dissolution if precipitation or phase separation occurs.

Conflicts

  • Strong oxidizers

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
5%
Sensitization risk Moderate

A direct CIR review for Glycol Salicylate is currently unavailable. However, related salicylates (e.g., methyl salicylate) have been deemed safe in cosmetics at concentrations where they are non-irritating and non-sensitizing. Glycol Salicylate is generally considered safe for cosmetic use, though careful handling is recommended to mitigate potential irritation or allergic reactions. It is classified as harmful if swallowed (H302) with an oral mouse LD50 of 1380 mg/Kg. Concerns regarding salicylate toxicity and Reye syndrome in children under 3 years of age, associated with related salicylates, should be noted. The FDA recognizes it as an active ingredient in topical analgesic products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While well-established as a topical analgesic, Glycol Salicylate lacks comprehensive clinical data specifically detailing its efficacy and safety for precision skincare benefits, meriting further investigation for these applications.

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