Science
Mechanism of Action
Glycofurol functions by increasing the solubility of poorly water-soluble, hydrophobic compounds within aqueous solutions, thereby improving their bioavailability. In topical applications, it significantly enhances the skin's penetration of active ingredients, facilitating their delivery into the dermal layers.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No data suggests Glycofurol is commonly 'dusted' or associated with specific dusting thresholds or red flags in cosmetic applications.
The Formula
Formulation
Stability
This ingredient is stable when stored under nitrogen in a well-closed, light-protected container in a cool, dry environment.
Conflicts
- Oxidizing agents
Safety
Safety Profile
Glycofurol is generally considered relatively nontoxic and nonirritant at typical pharmaceutical excipient levels. However, undiluted application can lead to irritation comparable to propylene glycol, and it is reported to cause serious eye irritation. While FDA-approved for specific parenteral uses (up to 50% v/v), cosmetic products do not undergo pre-market FDA approval, with manufacturers responsible for safety. EWG Skin Deep identifies high potential contamination concerns from impurities like Ethylene Oxide and 1,4-Dioxane, yet rates Glycofurol low for cancer, allergies, immunotoxicity, and developmental/reproductive toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glycofurol is a valuable formulation excipient, significantly enhancing the solubility and skin penetration of active ingredients; however, its CIR status is 'not reviewed,' and potential impurity concerns necessitate rigorous sourcing and quality control.
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