Science
Mechanism of Action
Glycine Hydrochloride delivers the amino acid glycine, which functions as a humectant to attract and bind water, significantly improving skin hydration. It stimulates collagen production, crucial for maintaining skin firmness and reducing the visibility of fine lines and wrinkles. Glycine also exhibits anti-inflammatory properties, calming irritated or sensitive skin, and its small molecular size allows for deeper penetration to promote skin repair and strengthen the skin barrier, thereby minimizing transepidermal water loss. Additionally, it helps stabilize product pH as a buffering agent.
Research
Clinical Evidence
Medium confidence4%
Transparency
Dusting Analysis
Glycine HCl is reported to be effective and safe within a concentration range up to 4%. This functional range indicates it is a truly active ingredient rather than one typically included at minimal levels for marketing purposes.
The Formula
Formulation
Stability
Glycine-HCl is commonly utilized in acidic buffer solutions, demonstrating stability around a pH of 3.0. For proper dissolution during preparation, the water temperature should be maintained at 25°C.
Conflicts
- strong acids
- strong bases
- strong oxidizing agents
- strong reducing agents
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has assessed Glycine, the parent compound, as safe for cosmetic use, with reported concentrations up to 4%. Glycine is also recognized as safe (GRAS) by the FDA for direct food additives. However, concentrated Glycine Hydrochloride requires protective handling due to its potential to cause severe skin burns and eye damage. An Ames test indicated negative results for mutagenicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glycine HCl is a valuable ingredient, offering significant hydrating, barrier-strengthening, and anti-aging benefits, suitable for a wide array of skin types and cosmetic formulations.
Related
Similar Ingredients
Finding similar ingredients…