Science
Mechanism of Action
As the smallest amino acid, Glycine readily penetrates the epidermal layers. It is integral to the skin's Natural Moisturizing Factor (NMF), effectively drawing and retaining moisture to optimize hydration and elasticity. Glycine also serves as a vital precursor for collagen, actively supporting its synthesis to bolster skin firmness, maintain structural integrity, and minimize the visibility of fine lines and wrinkles. Beyond structural support, it contributes to skin repair and barrier strengthening by reducing transepidermal water loss (TEWL). Its anti-inflammatory properties calm irritation and diminish redness, while its antioxidant capacity shields against oxidative stress. Furthermore, Glycine can help regulate sebum production and exert antibacterial effects, making it suitable for managing oily and blemish-prone skin.
Research
Clinical Evidence
High confidence0.2-1.5%
Key findings
- 01 Studies indicate that a concentration range of 0.2% to 1.5% for amino acids, including Glycine, delivers optimal skin rejuvenation and moisturization benefits.
- 02 In-vitro and in-vivo investigations confirm that amino acid complexes containing Glycine effectively reduce skin irritation and redness, concurrently enhancing moisturization.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Glycine exhibits high solubility in water, existing predominantly as an amphoteric zwitterion with pKa values around 2.34 (carboxyl group) and 9.6 (amino group). For optimal performance as an active ingredient, formulations should maintain a pH between 4.0 and 5.5. It also functions as a buffering agent. Solubility in ethanol is minimal, and it is insoluble in diethyl ether and hydrocarbons.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has deemed Glycine safe for topical cosmetic use based on current practices. While the Scientific Committee on Consumer Safety (SCCS) status is 'data unavailable', the FDA's concerns about high oral intake (GRAS status for food) do not apply to its topical application in skincare, further reinforced by its low irritancy and comedogenicity profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glycine is a valuable amino acid for all skin types, effectively enhancing hydration, supporting collagen synthesis, and providing soothing and protective benefits with a favorable safety profile.
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