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Moumoujus

GLYCERYL PABA.

Avoid CAS 136-44-7 / UV ABSORBER

Glyceryl PABA, or Glyceryl p-aminobenzoate, is an ester derivative of para-aminobenzoic acid (PABA) primarily recognized for its ultraviolet (UV) filtering capabilities. It functions to protect the skin by absorbing harmful UVB radiation and converting it into heat.

Summary

UV filter Skin-conditioning agent Stabilizer

Science

Mechanism of Action

This compound acts as a UV filter by directly absorbing ultraviolet light, specifically within the UVB spectrum. The absorbed energy is then safely dissipated as thermal energy, effectively preventing these damaging rays from penetrating the epidermal layers and causing cellular harm.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No specific information regarding the 'dusting' phenomenon for Glyceryl PABA is available in the provided research.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The parent compound, PABA, has shown stability in alcohol/glycerol solutions for 3 months when stored in darkness. However, high-dose UV irradiation can lead to the formation of azodibenzoic acid, indicating potential photo-instability under extreme conditions.

Conflicts

  • There is a risk of cross-sensitivity with other PABA derivatives, local anesthetics (e.g., benzocaine, procaine, tetracaine), sulfonamides, and certain dyes.
  • Contamination with benzocaine can precipitate adverse reactions in individuals known to be sensitive to benzocaine.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk High

Glyceryl PABA is an ester of PABA, an ingredient whose use has largely declined due to significant safety concerns including allergic dermatitis, photosensitivity, and a propensity to stain clothing. Glyceryl PABA itself is identified as a strong sensitizing agent, capable of causing allergic contact dermatitis. Evidence suggests PABA can penetrate the skin barrier, leading to systemic absorption. Some research also indicates potential thyroid-disrupting activity. Regulatory limits for PABA vary: the European Union lists it in Annex IV, permitting its use as a UV filter up to 5%, while the United States FDA regulates PABA use at a maximum concentration of 15%.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its UV filtering capabilities, Glyceryl PABA is not recommended for precision skincare formulations due to its high risk of allergic sensitization, potential for systemic absorption, and association with endocrine disruption.

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