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GLYCERYL DILAURATE.

Valuable CAS 27638-00-2 / SKIN CONDITIONING - EMOLLIENT, SURFACTANT - EMULSIFYING

Glyceryl Dilaurate is a lipid-derived ester primarily functioning as a skin conditioning agent, enhancing skin texture. It also plays a vital role in stabilizing cosmetic emulsions, ensuring uniform product consistency.

Summary

Skin Conditioning Emollient Surfactant Emulsifying Agent

Science

Mechanism of Action

On a molecular level, Glyceryl Dilaurate interacts with the skin's surface, providing emollient properties that soften and smooth. Furthermore, it acts as a surfactant and emulsifying agent, meticulously facilitating the stable blend of oil and water components within formulations.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 21-week investigation using a prototype lotion containing 0.5% Glyceryl Dilaurate indicated no evidence of epidermal scaling, inflammation, or neoplastic changes in biopsy specimens.
  2. 02 An eye shadow formulation with 1.5% Glyceryl Dilaurate did not induce skin irritation in a single patch test; however, a foundation containing the same concentration elicited mild skin irritation reactions in some individuals. Neither product at 1.5% was identified as a skin sensitizer.
  3. 03 In vitro DNA synthesis assays, conducted at concentrations up to 10 microg/ml, demonstrated that Glyceryl Dilaurate did not alter cell proliferation in normal human dermal fibroblasts.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

While the optimal pH range for Glyceryl Dilaurate's stability is not explicitly detailed, information for the related compound Glyceryl Laurate suggests stability between pH 4 and 8.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
5%
Sensitization risk Low

The CIR Expert Panel concluded that Glyceryl Dilaurate is safe for use in cosmetic and personal care products, contingent on ensuring the 1,2-diester form is not present at levels sufficient to cause biological effects. Rigorous testing for epidermal hyperplasia during product development is advised. Glyceryl Dilaurate holds approval from the FDA for use as an indirect food additive.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Glyceryl Dilaurate is a valuable ingredient, serving both as a skin conditioning emollient and a critical emulsifying agent for stable formulations, with a generally low sensitization risk but requiring careful formulation due to potential mild irritation at higher concentrations.

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