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Moumoujus

GLUTAMOYL AMINOGUANIDINE.

Insufficient Data / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Glutamoyl Aminoguanidine is a derivative of aminoguanidine, investigated for its potential to mitigate skin aging by inhibiting the formation of Advanced Glycation End Products (AGEs). It also exhibits antioxidant properties, aiming to reduce oxidative stress and foster an improved skin microenvironment.

Summary

Anti-aging Antioxidant Skin conditioning Anti-glycation

Science

Mechanism of Action

This ingredient operates primarily as a carbonyl trapping agent, reacting rapidly and efficiently with alpha,beta-dicarbonyl compounds such as methylglyoxal and glyoxal. This preemptive interaction prevents these precursors from advancing into harmful Advanced Glycation End Products (AGEs), which are significant contributors to skin aging. Additionally, it offers antioxidant benefits, helping to neutralize free radicals and alleviate oxidative stress in skin tissue. Supplementary mechanisms include potential promotion of keratinocyte proliferation and enhancement of the overall skin tissue microenvironment.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Aminoguanidine, a basic compound, exhibits pH-dependent stability. It is known to react with nitrous acid to form 5-aminotetrazole in acidic environments and tetrazene at neutral pH, indicating potential degradation or incompatibility with nitrites or similar compounds.

Conflicts

  • Nitrous acid (or nitrites, particularly in acidic or neutral pH environments due to reactive degradation products)
  • Alpha,beta-dicarbonyl compounds (as it actively reacts with these molecules as part of its primary mechanism, potentially depleting the active ingredient within the formulation)
  • Pyridoxal phosphate, pyruvate, glucose, malondialdehyde, and other biological nucleophiles (owing to its reactive nucleophilic nature)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Aminoguanidine (Pimagedine), the parent compound, was an investigational drug for diabetic complications, but systemic clinical trials were prematurely terminated due to documented safety concerns and insufficient efficacy. There is currently no specific safety assessment available from the Cosmetic Ingredient Review (CIR) for Aminoguanidine or its glutamoyl derivative as a cosmetic ingredient, highlighting a significant knowledge gap regarding its topical safety profile.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Glutamoyl Aminoguanidine demonstrates promising anti-glycation and antioxidant mechanisms primarily through in vitro and animal studies of its parent compound, the absence of specific cosmetic safety assessments and the prior termination of systemic trials for aminoguanidine due to safety concerns necessitate substantially more research before a definitive recommendation for precision skincare.

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