Science
Mechanism of Action
This ingredient impacts cellular pathways by acting as a ligand for the insulin receptor, activating the PI3K/Akt pathway which can lead to increased cellular glucose uptake. It significantly boosts the activity and expression of critical antioxidant enzymes, including superoxide dismutase (SOD) and catalase (CAT). Additionally, Glucosyl Stevioside has demonstrated anti-inflammatory properties and an ability to inhibit tumor promoters in murine skin-cancer models.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Glucosyl stevioside exhibits good stability under mild conditions, maintaining integrity within a pH range of 2.0 to 6.5 at 50°C over 72 hours. However, elevated temperatures and lower pH values significantly accelerate degradation, with up to 55% loss observed at pH 3 and 80°C, and complete degradation at pH 2 and 80°C over 72 hours. Its enzymatic modification specifically improves water dispersion and solubility compared to un-modified steviol glycosides.
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) has not assessed Glucosyl Stevioside for topical cosmetic use, glucosylated steviol glycosides are Generally Recognized as Safe (GRAS) by the FDA for oral consumption in food. An acceptable daily intake (ADI) for steviol glycosides is established at 4 mg/kg body weight/day based on oral consumption, where they have been deemed non-teratogenic and non-carcinogenic at recommended doses. Safety data specifically for topical cosmetic application is limited.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glucosyl Stevioside presents promising antioxidant and anti-inflammatory mechanisms with potential skin-softening benefits, but currently lacks sufficient topical clinical research to establish definitive efficacy in cosmetic applications.
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