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GLUCOMANNAN HYDROXYPROPYLTRIMONIUM CHLORIDE.

Insufficient Data CAS 1268336-96-4 / ANTISTATIC, HAIR CONDITIONING, HAIR FIXING, VISCOSITY CONTROLLING

A cationic polymer derived from Konjac Glucomannan, this ingredient serves as a multifaceted skin conditioner and film-former. It aids in enhancing skin hydration, reinforcing barrier integrity, and may offer targeted benefits for acne-prone skin.

Summary

Humectant Skin Conditioning Film-forming Anti-inflammatory (potential) Barrier Restoring (potential) Acne Treatment (potential) Antistatic Hair Conditioning Hair Fixative Viscosity Controlling

Science

Mechanism of Action

This ingredient, a derivative of glucomannan, forms a protective, humectant film on the skin's surface, effectively minimizing transdermal water loss and boosting hydration levels. Its inherent cationic charge facilitates binding to the negatively charged skin, delivering conditioning effects and establishing a protective layer. Further mechanisms include potential anti-inflammatory action, reduction of UV-induced erythema and DNA damage, assistance in unblocking skin pores, restoration of crucial skin barrier properties, and control of superficial microbial flora, which is particularly advantageous for individuals managing acne.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

5%

Transparency

Dusting Analysis

Not commonly dusted

No specific data on dusting properties was found for this ingredient.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Optimal dispersion and colloidal stability are observed under acidic to neutral conditions (pH 4.0-7.0); conversely, strongly alkaline environments (e.g., pH 10) can promote aggregation. This ingredient generally enhances overall product stability and extends shelf life. Similar cationic derivatives typically exhibit stability across a broad pH spectrum, with exceptions in strong acid and alkali solutions.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Moderate

While the base ingredient, Glucomannan, is recognized as a safe dietary fiber by the FDA, a specific Cosmetic Ingredient Review (CIR) assessment for GLUCOMANNAN HYDROXYPROPYLTRIMONIUM CHLORIDE is currently classified as 'insufficient data'. The CIR Expert Panel has concluded that broader classes of similar polysaccharides, like galactomannans (including some guar gum derivatives), are safe for cosmetic use, largely due to their substantial molecular size, which limits skin penetration. However, for a related ingredient, Hydroxypropyl Guar Hydroxypropyltrimonium Chloride, concentrations exceeding 1% may cause irritation, with a suggested safe use limit of up to 0.05% in cosmetics. Given these points and the absence of specific safety data for this precise derivative, a patch test is recommended, especially for individuals with sensitive skin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

GLUCOMANNAN HYDROXYPROPYLTRIMONIUM CHLORIDE demonstrates promising clinical efficacy for acne treatment and provides valuable conditioning and hydrating properties; however, its overall safety rating from CIR remains 'insufficient data', necessitating careful formulation and application.

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