Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

GERANYL ISOBUTYRATE.

Insufficient Data CAS 2345-26-8 / PERFUMING

Geranyl isobutyrate is an ester derived from geraniol, identified for its potential to mitigate inflammatory responses and inhibit bacterial growth. Preliminary *in vitro* data indicates its capacity to reduce pro-inflammatory cytokines and act against specific bacterial strains.

Summary

Anti-inflammatory Antimicrobial Fragrance

Science

Mechanism of Action

This compound is an ester that undergoes hydrolysis by esterases, releasing geraniol and isobutyric acid. Geraniol, a known active metabolite, is understood to interact with biological membranes and enzymes, thereby influencing cellular processes and membrane fluidity.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 At a concentration of 100 µg/mL, Geranyl Isobutyrate inhibited the production of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-alpha) by approximately 40%.
  2. 02 Exhibited effective inhibition against *Escherichia coli* at a Minimum Inhibitory Concentration (MIC) of 0.5 mg/mL.
  3. 03 Exhibited effective inhibition against *Staphylococcus aureus* at a Minimum Inhibitory Concentration (MIC) of 0.3 mg/mL.

Transparency

Dusting Analysis

Not commonly dusted

No data is available to suggest that Geranyl Isobutyrate is commonly 'dusted' or used at concentrations exceeding safe cosmetic limits for direct skin application in a manner that would raise concern.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Stable under acidic conditions, but prone to hydrolysis in environments of high humidity or in the presence of water with an acid or base catalyst, which leads to the formation of geraniol and isobutyric acid.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally Recognized as Safe (GRAS) for food use by FEMA. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) evaluated it in 1997, finding no safety concern at typical intake levels as a flavouring agent. PubChem reports that it does not meet GHS hazard criteria for 95.4% of all reports. While historically listed by the FDA as a permitted synthetic flavoring substance, some sources indicate a recent re-evaluation or removal of seven synthetic flavoring substances, potentially including this one.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While *in vitro* studies suggest potential anti-inflammatory and antimicrobial benefits, further *in vivo* research is required to ascertain its specific efficacy and optimal application in precision skincare formulations.

Related

Similar Ingredients

Finding similar ingredients…