Science
Mechanism of Action
This essential oil exerts its effects largely through the active compound germacrone, which has demonstrated *in vitro* antimicrobial efficacy. Beyond this, extracts from the plant are recognized for their multifaceted activities, including antioxidant, anti-inflammatory, antiseptic, and astringent properties, all contributing to overall skin health.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Demonstrated very high and selective *in vitro* antimicrobial activity against Bacillus subtilis, with effective concentrations ranging from 0.4 to 1.0 µg/ml in disc-diffusion and microdilution assays.
- 02 Exhibited kidney protection and antioxidant capabilities in an experimental murine model, ameliorating acute renal oxidative tissue damage. This effect was observed when used in combination with 200 mg kg⁻¹ gentamicin.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As an essential oil, this ingredient is inherently lipophilic and oil-soluble. Specific data regarding its optimal pH range for stability or other detailed stability parameters are not readily available.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) and SCCS have not conducted a specific safety assessment for Geranium macrorrhizum Flower/Leaf/Stem Oil. While essential oils are generally recognized as safe when utilized appropriately, a maximum concentration for cosmetic use has not been formally established for this particular species. It is important to note that CIR has reviewed Pelargonium Graveolens Flower Oil, a distinct species, not Geranium macrorrhizum.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While *in vitro* and preclinical studies suggest promising antimicrobial and antioxidant benefits, the absence of comprehensive human clinical data and specific safety assessments for topical cosmetic application necessitates further investigation for a definitive rating.
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References
Sources
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