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GAMMA-OCTALACTONE.

Questionable CAS 104-50-7 / PERFUMING

Gamma-octalactone is a cyclic lactone primarily recognized for its potent aromatic properties, delivering a sweet, creamy, coconut-like, and fruity scent. It is widely utilized as a fragrance ingredient within cosmetic and food applications. While contributing to the sensory experience of products, current research does not indicate any direct therapeutic or cosmetic benefits for skin.

Fragrance

Science

This compound functions purely as a scent molecule, imparting a distinct aromatic profile to formulations. No specific mechanism of action on skin for therapeutic or direct cosmetic benefits beyond its olfactive contribution has been identified in the available research.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Gamma-octalactone generally exhibits fair stability in most product types. Like other lactones, it may undergo polymerization over extended periods, potentially causing increased viscosity or phase separation in alcohol-based systems. It can be incorporated into soap formulations provided the soap is sufficiently matured.

Conflicts

  • strong reducing agents
  • strong bases
  • strong oxidizing agents

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

The Research Institute for Fragrance Materials (RIFM) has evaluated gamma-octalactone for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, phototoxicity/photoallergenicity, and skin sensitization, concluding no safety concern at current use levels. It is recognized by the FDA as a flavoring agent. However, the European Chemicals Agency (ECHA) classifies it as causing skin irritation (H315) and as harmful to aquatic life. Other reports, including RTECS and Alfa Aesar MSDS, classify it as a moderate skin irritant and strong eye irritant. Contrasting these findings, one human experience reported no irritation or sensitization at a 12% solution.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

Primarily a fragrance agent, Gamma-octalactone offers no identified skincare benefits and presents conflicting data regarding its potential for skin irritation.


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