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Moumoujus

GALACTOSE DEHYDROGENASE.

Insufficient Data CAS 9028-54-0 / SKIN CONDITIONING

Galactose Dehydrogenase is an enzyme that precisely catalyzes the dehydrogenation of β-D-galactose, yielding D-galactose-1,5-lactone and NADH. This enzymatic action suggests a potential role in modulating skin redox states and contributing to antioxidant defense pathways.

Summary

Skin conditioning Antioxidant Redox modulation

Science

Mechanism of Action

Operating optimally within a pH range of 7.0 to 8.6, Galactose Dehydrogenase facilitates the conversion of β-D-galactose pyranose to D-galactose-1,5-lactone, simultaneously producing NADH from NAD+. A specific variant, L-galactose dehydrogenase, is known in plants for its role in L-galactono-1,4-lactone production, a precursor to Vitamin C. When applied to skin, this enzyme's mechanism could theoretically contribute to antioxidant pathways through lactone production, participate in redox reactions, and modulate NAD/NADH levels, thereby influencing cellular energy and defense.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data suggests this enzyme is commonly 'dusted' or used at ineffective concentrations. Its enzymatic nature implies a specific concentration would be required for activity, making 'dusting' unlikely.

The Formula

Formulation

Solubility
Water
Optimal pH 7 – 8.6
0 7 14

Stability

Optimal enzymatic activity is observed between pH 7.0 and 8.6, with significant instability reported below pH 5.0. The enzyme is sensitive to oxidative damage and its activity is strongly inhibited by sulfhydryl group inhibitors, as well as by Cu⁺⁺, Zn⁺⁺, and Fe⁺⁺ ions. High concentrations of ascorbic acid do not substantially impact its activity, though pH shifts can influence reported inhibition.

Conflicts

  • sulfhydryl group inhibitors
  • Cu⁺⁺
  • Zn⁺⁺
  • Fe⁺⁺
  • oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While listed as a cosmetic ingredient for skin conditioning, specific safety assessments from major regulatory bodies such as CIR, SCCS, or FDA are not available in the current research. Its overall safety profile for dermatological application is not extensively documented.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Despite exhibiting a theoretically compelling enzymatic mechanism suggesting benefits in redox modulation and antioxidant support, the absence of robust clinical efficacy data and comprehensive safety assessments for topical application renders its current integration questionable without further scientific validation.

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