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Moumoujus

FROG OOCYTE EXTRACT.

Insufficient Data CAS 1955522-56-1 / SKIN CONDITIONING

Frog Oocyte Extract, particularly the Bioquantine™ form derived from electroporated Xenopus laevis oocytes, represents a biological complex extensively utilized in cell biology. In skincare, it demonstrates a nascent potential to influence fundamental cellular renewal and repair processes, aiming to support skin regeneration.

Summary

Skin regeneration Cellular renewal Cellular repair

Science

Mechanism of Action

The mechanism of action for Frog Oocyte Extract, specifically from electroporated Xenopus laevis oocytes (Bioquantine™), involves a complex interplay of its constituents. This extract contains key proteins such as vitellogenin-A2 and cofilin-1-A, alongside a profile of microRNAs including hsa-miR-17-5p and the miR-302 family. These components are known to be involved in crucial cellular dynamics, including cell cycle progression, DNA replication, and somatic cell reprogramming, which collectively suggest an ability to promote cellular renewal and repair pathways beneficial for skin regeneration.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In a murine model, daily intraperitoneal injections of Bioquantine™ (an extract of electroporated Xenopus laevis frog oocytes) at a concentration of 5 mg/ml for 25-45 days exhibited skin regeneration in a squalene-monohydroperoxide-induced wrinkling model.

Transparency

Dusting Analysis

Not commonly dusted

There is no evidence in the provided research data to suggest that Frog Oocyte Extract is commonly 'dusted' in cosmetic formulations. The available efficacy data pertains to an injected murine model, making a dusting threshold for topical application irrelevant at this stage.

The Formula

Formulation

Solubility
Water
Optimal pH 7.6 – 8
0 7 14

Stability

Frog oocyte extracts are highly sensitive to both temperature and enzymatic degradation. They are optimally stable in a pH range of 7.6-8.0, and protease inhibitors are typically added during preparation to maintain integrity. While Xenopus laevis extracts can be stored at 16°C for 5-6 hours, Xenopus tropicalis extracts should not be placed on ice as it impairs their activity. For extended preservation, snap-freezing and storage at -80°C are recommended. High concentrations of salt can lead to the disassembly of protein complexes within the extract.

Conflicts

  • Proteolytic enzymes (proteases)
  • Extreme temperatures
  • High salt concentrations

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No direct safety assessments specifically for 'Frog Oocyte Extract' or 'Xenopus Oocyte Extract' as a cosmetic ingredient have been conducted by regulatory bodies such as CIR or SCCS. The FDA's VCRP does not list its reported use. While the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) is a method for developmental toxicity testing, it does not provide a safety status for the ingredient itself in cosmetic applications. Therefore, comprehensive safety data for topical cosmetic use is currently unavailable.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Frog Oocyte Extract demonstrates potential for skin regeneration in laboratory models, the lack of human clinical trials and comprehensive cosmetic safety assessments makes its suitability for topical applications currently unconfirmed.

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