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Moumoujus

FISH GLYCERIDES.

Valuable CAS 100085-40-3 / SKIN CONDITIONING - EMOLLIENT

Fish Glycerides are a potent source of omega-3 polyunsaturated fatty acids (PUFAs), including DHA and EPA, recognized for their critical role in modulating cutaneous inflammation and fortifying the skin's natural barrier. They function as effective emollients, providing superior skin conditioning and deep hydration.

Summary

emollient skin conditioning

Science

Mechanism of Action

These glycerides deliver omega-3 polyunsaturated fatty acids (PUFAs), such as Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA), to the skin. These PUFAs work by mitigating cutaneous inflammation through competitive inhibition of inflammatory arachidonic acid and subsequent suppression of pro-inflammatory eicosanoid production. They also regulate cytokine activity, supporting wound healing, enriching membrane phospholipids to suppress UVR-induced inflammatory responses, and enhancing skin barrier integrity and hydration.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of 200 mg of sardine oil extract, rich in EPA and DHA, significantly reduced UVB-induced erythema in human trials.
  2. 02 Oral supplementation with fish oil (1.2 g DHA and 2.8 g EPA daily for 4 weeks) significantly increased the minimal erythema dose to UVB and reduced serum triglyceride levels.
  3. 03 Oral fish oil supplementation increased cutaneous hydration by 30% after 60 days and reduced dryness and pruritus in an acetone-induced dry skin rat model.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As fish glycerides contain a high proportion of polyunsaturated fatty acids, they are highly prone to oxidative degradation, leading to rancidity. Formulation stability is influenced by emulsifier type and concentration, and pH, with protein-based emulsifiers at higher pH (e.g., pH 7) showing improved oxidative stability. The inclusion of potent antioxidants is critical to preserve product integrity.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has assessed fish glycerides, as part of a larger group of 51 triglycerides, and concluded their safety for use in cosmetics under current practices and concentrations. The EPA also identifies 'Fats and Glyceridic oils, fish' as 'Fish oil' (CAS 8016-13-5).

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

A valuable ingredient for enhancing skin barrier integrity, reducing inflammatory responses, and providing significant hydration, particularly beneficial for compromised or sensitive skin.

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