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Moumoujus

FERROUS GLYCINATE.

Insufficient Data CAS 20150-34-9 / ANTIOXIDANT, SKIN CONDITIONING

Ferrous Glycinate, also known as Ferrous Bisglycinate, is a chelated compound uniting ferrous iron (Fe²⁺) with the amino acid glycine. While primarily recognized as an oral iron supplement, its fundamental components, iron and glycine, are pivotal for maintaining healthy skin structure and function when considered individually.

Summary

Skin Cell Regulation Collagen Booster Moisture Enhancement Skin Regeneration Support

Science

Mechanism of Action

This ingredient contributes to skin health through the independent actions of its constituents. Iron is indispensable for normal skin, hair, and nail development, actively regulating the proliferation and differentiation of skin cells and thereby influencing cellular turnover. Glycine is valued in skincare for its capacity to enhance skin hydration, stimulate collagen synthesis, and support overall skin repair and regeneration. The chelated structure of ferrous glycinate is designed to augment its chemical stability and compatibility within formulations, helping to mitigate oxidation and undesirable interactions. However, it is crucial to note that excessive iron, particularly under oxidative stress, carries a theoretical risk of generating reactive oxygen species via the Fenton-Haber-Weiss reaction, which can induce lipid oxidation. Specific topical mechanisms beyond the general roles of iron and glycine are not explicitly defined in current research.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data regarding 'dusting' as a cosmetic application concern for Ferrous Glycinate was found in the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Ferrous Glycinate exhibits hygroscopic properties. Its chelated design significantly improves its chemical stability and overall ingredient compatibility, which aids in reducing oxidation and preventing unwanted interactions within complex formulations, potentially extending product shelf-life. Its stability across various pH levels and temperatures is considered acceptable for typical uses. A 1% solution of Ferrous Bisglycinate typically presents a pH of approximately 8. Notably, it has shown enhanced resistance to oxidation in oily bases, outperforming traditional iron salts.

Conflicts

  • Potential for lipid peroxidation if the chelate's integrity is compromised, leading to the release and oxidation of iron.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Ferrous Bisglycinate Chelate holds Generally Recognized As Safe (GRAS) status by the FDA for its use in foods as a dietary iron source, and has JECFA approval for supplementation and fortification within tolerable daily intake limits. While Ferrous Glycinate (CAS # 20150-34-9) is listed in the EU CosIng database, suggesting its cosmetic ingredient status, there is currently no specific safety assessment from the Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) for topical application, nor are maximum concentration guidelines provided in the research.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While the individual components (iron and glycine) offer theoretical benefits for skin health and the chelated form enhances stability, there is a critical absence of specific topical clinical efficacy studies and cosmetic safety assessments for Ferrous Glycinate, rendering its direct skin benefits and safety profile for cosmetic use largely unverified at this time.

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