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Moumoujus

FERRIC NITRATE.

Avoid CAS 7782-61-8 / NOT REPORTED

Ferric Nitrate acts as a precursor to nitric oxide (NO) in the skin, a molecule with broad potential benefits including anti-inflammatory, antimicrobial, and antioxidant properties. However, it is explicitly classified as a potent skin and eye irritant with no established safe maximum concentration for cosmetic application.

Summary

Nitric Oxide Precursor Potential Anti-inflammatory (indirect) Potential Antimicrobial (indirect) Potential Antioxidant (indirect) Potential Wound Healing Support (indirect)

Science

Mechanism of Action

Ferric nitrate serves as a precursor to nitric oxide (NO) via the nitrate-nitrite-NO pathway within the skin. Nitric oxide is a critical signaling molecule known for its anti-inflammatory, immunomodulatory, antimicrobial, and vasodilatory capabilities, also contributing to wound healing processes. It plays a role in mediating UV-induced skin responses like erythema and edema, influences melanogenesis, and exhibits antioxidant qualities by scavenging reactive oxygen species and preventing lipid peroxidation. Additionally, nitric oxide may offer protection against UVA-induced cellular damage, potentially inhibiting photoaging and supporting broad-spectrum antimicrobial actions.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Ferric Nitrate's primary applications are in industrial sectors such as dyeing, metal finishing, and water treatment, indicating it is not a typically 'dusted' ingredient within cosmetic or personal care product categories.

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 5.5
0 7 14

Stability

Ferric nitrate, a pale-violet hygroscopic solid, dissolves readily in water. Its aqueous solutions tend to hydrolyze, forming a yellow color, which suggests instability in formulations with a neutral to alkaline pH. Stability is enhanced in acidic environments, often achieved by incorporating small amounts of nitric acid. Solutions containing ferric nitrate are corrosive to most metals.

Conflicts

  • Organic substances
  • Reducing agents
  • Combustible materials
  • Metals

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Ferric nitrate is classified as a strong oxidant and a known irritant to both skin and eyes, capable of causing serious irritation. Inhalation of its dust can irritate the respiratory tract, and extended skin contact may lead to irritation or inflammation, potentially worsening pre-existing dermatitis conditions. Ferric salts are generally recognized for their skin irritant properties.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its theoretical role as a nitric oxide precursor with potential benefits, Ferric Nitrate's pronounced skin and eye irritancy, coupled with its industrial common uses and lack of cosmetic safety assessment, renders it unsuitable for skincare formulations.

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