Science
Mechanism of Action
The anti-inflammatory mechanism observed in Farfugium japonicum essential oil involves the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production, accompanied by dose-dependent decreases in iNOS and COX-2 mRNA expression. Additionally, specific compounds isolated from the plant have demonstrated anti-inflammatory activity by inhibiting superoxide anion generation in human neutrophils.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In vitro studies indicate that Farfugium japonicum essential oil, at a concentration of 100 µg/mL, exhibited low cytotoxicity in human dermal fibroblast and keratinocyte HaCaT cells. It also inhibited LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells, suggesting potential anti-inflammatory effects for topical application.
- 02 Specific compounds (15 and 16) isolated from methanolic extracts of Farfugium japonicum var. formosanum, when tested at 10 µg/mL, inhibited superoxide anion generation by human neutrophils by 92.0% and 87.3% respectively, indicating notable anti-inflammatory activity.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While the Farfugium japonicum plant has been identified as a 'toxic plant' when distinguished from edible species, in vitro studies of its essential oil at 100 µg/mL reported low cytotoxicity in human dermal fibroblast and keratinocyte cells. No specific CIR, SCCS, or FDA safety assessments are available for FARFUGIUM JAPONICUM STEM EXTRACT. Paula's Choice currently lists the ingredient as 'unclassified' with 'no known benefits' as of their last review.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite promising in vitro indicators of anti-inflammatory and skin conditioning potential, the limited efficacy and safety data specific to the stem extract in topical applications warrants further research.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources
Keep exploring
From ingredients to everyday care.
Sensitive skin ↗
Start with comfort, product choices and the questions to ask.
Barrier support ↗
Understand moisture, lipids and the limits of ingredient claims.
Ingredient names help you read a label. They do not establish how a finished product will perform. Explore The Garden.