EUPHORBIA ESULA EXTRACT.

Due to the significant inherent irritancy and toxicity, particularly from diterpene esters in its unprocessed form, Euphorbia esula extract is not an ingredient typically 'dusted' or used widely in cosmetic formulations without extensive, proprietary processing to remove harmful compounds. Its fundamental safety concerns preclude common application at any concentration.

The Cosmetic Ingredient Review (CIR) has listed Euphorbia esula extract for potential future assessment but has not issued a final safety determination. The milky white latex sap of the plant is unequivocally known to cause contact dermatitis ranging from mild to severe, and direct eye contact can lead to temporary or permanent damage. Ingesting the plant material can induce blistering of the lips and oral mucosa. The primary toxic principles are identified as diterpene esters and toxic diterpene ingenols. Consequently, the raw plant material and any unprocessed extracts are deemed to possess significant irritant and toxic properties.