Science
Mechanism of Action
This extract modulates several skin pathways. It acts as an anti-inflammatory agent by notably inhibiting the release of pro-inflammatory cytokines, specifically TNF-α and IL-6, and reducing oxygen radical generation and vascular permeability. As an antioxidant, it directly scavenges superoxide anion radicals and DPPH free radicals, while also enhancing endogenous antioxidant defenses like superoxide dismutase (SOD) and reducing oxidative stress markers such (MDA) and (MPO). For anti-pigmentation, it appears to inhibit tyrosinase activity and melanin synthesis, potentially through mechanisms involving HSP70 upregulation, which also helps mitigate UVB-induced damage. Additionally, it offers humectant properties, aiding in moisture retention within formulations, and may possess antimicrobial activity against common skin bacteria like Propionibacterium acnes and Staphylococcus epidermidis.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Water extract and residue water extract exhibited significant superoxide anion radical scavenging activity, achieving inhibition rates of 94.55% and 95.77% respectively, at a concentration of 400 µg/ml.
- 02 Residue water extract (RWE), n-butanol fraction (BF), and water extract (WE) demonstrated DPPH scavenging activities of 72.15%, 70.17%, and 68.55% respectively at 133.33 µg/mL. Their respective IC50 values were 70.56 µg/mL, 74.99 µg/mL, and 83.37 µg/mL.
- 03 Flowers of Eupatorium lindleyanum showed a notable inhibitory effect on the release of inflammatory factors TNF-α and IL-6.
- 04 Specific isolated compounds (EA and EB) from E. lindleyanum, at 10 µg/ml, upregulated HSP70 in skin cells, which aided in alleviating UVB radiation damage and inhibiting melanin production.
Transparency
Dusting Analysis
While promising in vitro studies demonstrate significant antioxidant, anti-inflammatory, and anti-pigmentation potential, the absence of human in vivo topical efficacy data prevents a precise determination of effective cosmetic concentrations and comprehensive skin benefits, making broad claims based solely on current research potentially premature.
The Formula
Formulation
Stability
No specific optimal pH range for stability has been identified. However, extraction methods involving water and ethanol suggest a primarily water-soluble nature for its active components.
Safety
Safety Profile
Toxicological information, particularly regarding clinical safety for topical cosmetic application, is limited. Oral animal studies indicated no significant toxicity at high concentrations (LD50 value of 225.6 g (herb)/kg in rats). While traditional oral applications also suggest safety, further comprehensive toxicological studies are necessary to fully ascertain its safety profile for cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eupatorium Lindleyanum Extract shows promising in vitro bioactivities, including antioxidant and anti-inflammatory effects, but comprehensive human in vivo data is required to establish its precise topical efficacy and safety for cosmetic applications.
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References
Sources