Science
Mechanism of Action
This extract operates through multiple anti-inflammatory pathways. It has been shown to suppress MAPK (ERK, JNK, p38) and NF-κB (IκBα, p65) signaling, critical cascades in inflammatory responses. Furthermore, it reduces COX-2 expression, inhibits the PI3K/AKT pathway, and downregulates key inflammatory cytokines such as IL-13 and IL-4, along with chemokines like CCL22 and CCL17. Crucially, it also supports epidermal integrity by restoring filaggrin expression, thereby enhancing skin barrier function.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
No data available to suggest common dusting or specific dusting thresholds for this ingredient in cosmetic applications.
The Formula
Formulation
Safety
Safety Profile
While the Euonymus genus generally contains toxic compounds in various parts, specific dermal safety assessments by regulatory bodies such as CIR, SCCS, or FDA for Euonymus Sachalinensis Bark Extract in cosmetic applications are currently unavailable. Consequently, its dermal toxicity and sensitization risk remain undetermined, warranting caution.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite promising in vitro and animal model data demonstrating potent anti-inflammatory and barrier-restoring effects, the absence of comprehensive dermal safety assessments and human clinical data for cosmetic application currently limits a definitive recommendation.
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References
Sources