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Moumoujus

EUGENYL ACETATE.

Avoid CAS 93-28-7 / FRAGRANCE

Eugenyl Acetate is an aromatic ester, derived from eugenol, that exhibits antibacterial, anti-inflammatory, and antioxidant properties. While it primarily functions as a perfuming and masking agent, regulatory bodies classify it as a fragrance allergen due to its potential to form sensitizing compounds on the skin.

Summary

Perfuming Masking Antioxidant Anti-inflammatory Antibacterial

Science

Mechanism of Action

This ingredient works through multiple biological pathways, including the inhibition of NF-κB, a central mediator in inflammatory cascades. It also enhances the expression of p53 and p21 (WAF1), which are crucial for cell cycle regulation and apoptosis, suggesting a role in skin protection. Furthermore, Eugenyl Acetate can reduce pro-inflammatory cytokine activity in human dermal fibroblasts.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Eugenyl Acetate is not stable in high pH or alkaline environments, such as those typically found in white soap formulations, leading to degradation. Over time, acetates can also undergo hydrolysis, potentially forming acetic acid.

Conflicts

  • High pH or alkaline formulations (e.g., white soap) should be avoided due to instability and degradation.
  • Formulators must also consider the potential for Eugenyl Acetate to hydrolyze within the skin, which can produce sensitizing compounds.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) has determined that there is 'insufficient data' for a comprehensive safety assessment of Eugenyl Acetate. While the Research Institute for Fragrance Materials (RIFM) found no evidence of skin sensitization at concentrations up to 50% in murine local lymph node assays and 8% in human repeat insult patch tests, the Scientific Committee on Consumer Safety (SCCS) classifies it as a fragrance allergen. This classification stems from its potential to hydrolyze in the skin, yielding sensitizing compounds, leading to its inclusion in Annex III of the EC Cosmetics Regulation with usage restrictions. In California, reporting is mandated for concentrations at or above 0.01% in rinse-off products and 0.001% in leave-on products. It is recognized as GRAS (Generally Recognized As Safe) by the FDA when used as a flavoring agent.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Avoid

While Eugenyl Acetate presents intriguing antibacterial, anti-inflammatory, and antioxidant properties, its classification as a fragrance allergen, with a risk of hydrolysis into sensitizing compounds, warrants its avoidance in precision skincare applications.

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