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Moumoujus

EUCALYPTUS CITRIODORA LEAF EXTRACT.

Avoid CAS 8000-48-4 / SKIN CONDITIONING

Eucalyptus Citriodora Leaf Extract offers a spectrum of skin benefits, acting as a potent anti-inflammatory, antimicrobial, and antioxidant agent. It supports healthy skin barrier function, aids in moisturization, and may assist in managing acne and reducing signs of aging.

Summary

Anti-inflammatory Antimicrobial Antioxidant Skin Conditioning Barrier Support Anti-Acne Anti-Aging Skin Brightening Perfuming

Science

Mechanism of Action

This extract exerts its anti-inflammatory effects by modulating the peroxisome proliferator-activated receptor-delta (PPAR-delta) pathway, leading to a suppression of pro-inflammatory cytokines such as IL-6 and IL-8; the presence of 1,8-cineole further contributes to this action. Its antimicrobial, antibacterial, and antiseptic properties combat undesirable microorganisms. Rich in phenolic compounds and flavonoids, it provides robust antioxidant protection against oxidative stress. It supports skin barrier repair and hydration, and may help clarify clogged pores and regulate oil production, potentially through salicylic acid-like components. Additionally, it demonstrates anti-allergic potential by inhibiting histamine activity, promotes keratinocyte proliferation, and may stimulate ceramide production for enhanced skin brightness.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An in-vitro study demonstrated that Eucalyptus Citriodora extract at 250 µg/ml suppressed LPS-induced IL-6 and TNF-α-induced IL-8 production from HaCaT cells, evidencing significant anti-inflammatory activity. The study also highlighted its ability to promote keratinocyte differentiation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Specific optimal pH ranges for the stability of Eucalyptus Citriodora Leaf Extract are not readily available. However, a formulated hand sanitizer containing Eucalyptus citriodora essential oil was stable at a pH of 5.41, and an aqueous extract of a related species (Eucalyptus camaldulensis) showed a skin-compatible pH of 6.

Conflicts

  • Alcohol-based products (potential for drying)
  • Direct contact with eyes and mucous membranes
  • Use during pregnancy/breastfeeding (specifically for the essential oil due to general caution)

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

The Cosmetic Ingredient Review (CIR) has not specifically assessed Eucalyptus Citriodora Leaf Extract. While a CIR safety assessment for Eucalyptus globulus-derived ingredients suggested safety in cosmetics when non-sensitizing, with a maximum leave-on concentration of 0.4% for Eucalyptus Globulus Leaf Oil, this recommendation is for a different Eucalyptus species. INCIDecoder notes a high EU sensitizer total percentage of 20% for Eucalyptus Citriodora Oil, indicating a substantial risk of sensitization and irritancy, especially for sensitive skin. Despite some studies reporting no side effects for specific formulations of Eucalyptus citriodora essential oil or Eucalyptus camaldulensis extract, a general caution is advised due to its high irritancy potential. Use is contraindicated during pregnancy and breastfeeding, particularly for the essential oil form.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its diverse potential benefits, Eucalyptus Citriodora Leaf Extract presents a high risk of irritation and sensitization, making its application in precision skincare questionable and generally advised against for broader use.

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