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Moumoujus

ETHYLENEDIAMINE.

Avoid CAS 107-15-3 / NOT REPORTED

Ethylenediamine is a foundational organic compound recognized for its strong chelating properties. While historically employed as a stabilizer in certain dermatological formulations, its direct application in skincare is now largely contraindicated due to significant safety concerns.

Summary

Chelating Agent Historical Stabilizer

Science

Mechanism of Action

Ethylenediamine functions primarily as a potent chelating agent. It possesses the ability to form stable complexes with various metal ions, such as calcium and iron. This action sequesters these ions, preventing them from inducing undesirable reactions that can compromise the texture, stability, and overall integrity of cosmetic formulations.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Information regarding 'dusting' properties of ethylenediamine in cosmetic applications is not available in the provided research data.

The Formula

Formulation

Solubility
Both
Optimal pH ≥11.9
0 7 14

Stability

Ethylenediamine is a notably strong base; a 25% solution exhibits a pH of 11.9 at 25°C. Its pronounced alkalinity means it can readily absorb carbon dioxide from the atmosphere, leading to the formation of nonvolatile carbonates, which may impact formulation stability.

Conflicts

  • strong acids (e.g., acetic acid, nitric acid, sulfuric acid, chlorosulfonic acid, fuming sulfuric acid)
  • acetic anhydride
  • carbon disulfide
  • silver perchlorate
  • oxidizing substances

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Ethylenediamine itself is extensively documented as a potent skin and respiratory irritant and sensitizer, frequently causing contact dermatitis, leading to its removal from many dermatological preparations. It has not been reviewed by the CIR Expert Panel for direct cosmetic use and is explicitly listed by Health Canada as banned or unsafe for cosmetics. The FDA's listing is confined to specific, limited applications in food contact materials, not for direct cosmetic application. It is crucial to distinguish this from its derivatives, such as Trisodium Ethylenediamine Disuccinate, which the CIR Expert Panel has deemed safe for cosmetic use at concentrations up to 0.64% with low associated risks.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its documented high potential for skin irritation and sensitization, coupled with regulatory advisories against its use in cosmetics, ethylenediamine is unequivocally recommended to be avoided in skincare formulations.

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