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Moumoujus

ETHYL TAFLUPROSTAMIDE.

Insufficient Data / HAIR CONDITIONING, NAIL CONDITIONING

Ethyl Tafluprostamide is a synthetic prostaglandin analog, specifically a derivative known for its highly lipophilic nature. In cosmetics, it is primarily integrated into formulations targeting hair, eyelash, and eyebrow enhancement, acting through a distinct biological mechanism to influence growth.

Summary

Hair conditioning Nail conditioning

Science

Mechanism of Action

As a synthetic prostaglandin analog, Ethyl Tafluprostamide operates by first entering cells via a specific prostaglandin transporter (PGT) due to its lipophilic properties. Once inside, it engages and binds to G-protein coupled receptors (GPCRs), which are instrumental in mediating cellular responses by activating or inhibiting enzymes, triggering downstream physiological effects. This mechanism is known to promote eyelash growth and is also linked to the regulation of intraocular pressure.

Research

Clinical Evidence

Low confidence
Effective range 0.0018–0.018%
Optimal

0.018%

Key findings

  1. 01 An in vitro percutaneous absorption study on human skin demonstrated 6.51% ± 2.16% absorption when applied at a 0.018% concentration.
  2. 02 A Human Repeat Insult Patch Test (HRIPT) involving 51 panelists showed no skin irritation at a concentration of 0.025%.
  3. 03 Both in vitro (EpiOcularTM RhCE assay, HET-CAM assay) and in vivo studies (daily use for 28 days in an eyelash product at 0.018% or 0.025%) reported no ocular irritation.
  4. 04 Commercial eyelash growth serums typically contain Ethyl Tafluprostamide in concentrations ranging from 0.0018% to 0.0176%. Cosmetic manufacturers have sought approval for a maximum concentration of 0.018% in cosmetic products within the EU Commission.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This ingredient exhibits hygroscopic properties, necessitating storage in a tightly sealed container. It should be maintained in a cool (2-8°C), dry, and well-ventilated environment, away from heat, sparks, and flame, and ideally stored under an inert gas atmosphere to preserve its integrity.

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
0.018%
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) currently deems the available data insufficient for a formal safety review, noting significant data gaps. Similarly, the Scientific Committee on Consumer Safety (SCCS) has been unable to conclude on its safety at intended cosmetic concentrations, such as 0.018%, citing concerns regarding the potent pharmacological activity of prostaglandin analogues and their use near the eye. Furthermore, the FDA often regulates products making efficacy claims related to prostaglandin analogs as drugs. Users should be aware that common or very common side effects associated with prostaglandin analogs include ocular discoloration, discomfort, inflammation, and disorders, as well as headaches, hypertension, hypertrichosis, skin reactions, and vision disturbances.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Due to insufficient safety data from regulatory bodies like CIR and SCCS, coupled with concerns regarding its potent pharmacological activity and potential for drug-like regulation, Ethyl Tafluprostamide's use in cosmetics carries significant regulatory and safety questions.

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