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Moumoujus

ETHYL DICARBOETHOXY PANTOTHENATE.

Insufficient Data / SKIN CONDITIONING

Ethyl Dicarboethoxy Pantothenate (EDCEP), a derivative of pantothenic acid, shows promising efficacy in protecting skin cells from damage induced by environmental pollutants. It achieves this by fortifying the skin's natural antioxidant defenses and modulating inflammatory pathways.

Summary

Antioxidant Anti-Pollution Anti-inflammatory

Science

Mechanism of Action

EDCEP reduces cellular damage primarily by stimulating the intracellular defense system against Reactive Oxygen Species (ROS) via Nrf2 activation. It also interferes with the aryl hydrocarbon receptor (AHR) signaling pathway, which is implicated in pollutant-induced skin responses. Furthermore, EDCEP suppresses the secretion of the pro-inflammatory cytokine tumor necrosis factor (TNF-α) and mitigates the formation of carbonylated proteins, key markers of oxidative damage.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Ethyl 2,4-dicarboethoxy pantothenate (EDCEP) reduced cellular damage from environmental pollutants by activating Nrf2 and interfering with AHR signaling. It also suppressed TNF-α secretion and lowered carbonylated protein levels in human epidermal equivalents exposed to diesel particulate extract (DPE), as well as reducing intracellular ROS levels stimulated by DPE or H2O2.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While several pantothenic acid derivatives (e.g., Panthenol, Calcium Pantothenate) have been evaluated and deemed safe by the Cosmetic Ingredient Review (CIR) Expert Panel, Ethyl Dicarboethoxy Pantothenate itself has not undergone a formal review. Formulators should exercise caution as related derivatives may contain residual amines, necessitating care to avoid the potential formation of N-nitroso compounds in cosmetic products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Ethyl Dicarboethoxy Pantothenate demonstrates intriguing anti-pollution and antioxidant properties in initial studies, but a comprehensive safety review and further clinical data, particularly regarding effective concentrations, are needed for a definitive assessment.

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